Do brain T2/FLAIR white matter hyperintensities correspond to myelin loss in normal aging? A radiologic-neuropathologic correlation study

Haller, Sven; Kovari, Eniko Veronika; Herrmann, François; Cuvinciuc, Victor; Tomm, AM; Zulian, Gilbert; Lövblad, Karl-Olof; Giannakopoulos, Panteleimon; Bouras, Constantin

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Title		Do brain T2/FLAIR white matter hyperintensities correspond to myelin loss in normal aging? A radiologic-neuropathologic correlation study
Authors		Haller, Sven Kovari, Eniko Veronika Herrmann, François Cuvinciuc, Victor Tomm, AM Zulian, Gilbert Lövblad, Karl-Olof Giannakopoulos, Panteleimon Bouras, Constantin show all authors [1 - 9]
Published in		Acta Neuropathologica Communications. 2013, vol. 1, no. 1, p. 14
Abstract		White matter hyperintensities (WMH) lesions on T2/FLAIR brain MRI are frequently seen in healthy elderly people. Whether these radiological lesions correspond to irreversible histological changes is still a matter of debate. We report the radiologic-histopathologic concordance between T2/FLAIR WMHs and neuropathologically confirmed demyelination in the periventricular, perivascular and deep white matter (WM) areas.
Identifiers		DOI: 10.1186/2051-5960-1-14 PMID: 24252608
Full text		Article (Published version) (2.1 MB) - Free access
Structures		Faculté de médecine / Section de médecine clinique / Département de psychiatrie Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale Faculté de médecine / Section de médecine clinique / Département de médecine interne générale, de réhabilitation et de gériatrie
Research groups		Démence du sujet âgé, troubles cognitifs, la symptomatologie cognitive (577) Ischémie cérébrale et connectivité (801) Groupe Giannakopoulos Panteleimon (psychiatrie générale) (201) Médecine et soins palliatifs (709)
Citation (ISO format)		HALLER, Sven et al. Do brain T2/FLAIR white matter hyperintensities correspond to myelin loss in normal aging? A radiologic-neuropathologic correlation study. In: Acta Neuropathologica Communications, 2013, vol. 1, n° 1, p. 14. https://archive-ouverte.unige.ch/unige:31357