Do brain T2/FLAIR white matter hyperintensities correspond to myelin loss in normal aging? A radiologic-neuropathologic correlation study

Haller, Sven; Kovari, Eniko Veronika; Herrmann, François; Cuvinciuc, Victor; Tomm, AM; Zulian, Gilbert; Lövblad, Karl-Olof; Giannakopoulos, Panteleimon; Bouras, Constantin

doi:10.1186/2051-5960-1-14

Scientific article

English

Do brain T2/FLAIR white matter hyperintensities correspond to myelin loss in normal aging? A radiologic-neuropathologic correlation study

ContributorsHaller, Sven; Kovari, Eniko Veronika; Herrmann, François; Cuvinciuc, Victor; Tomm, AM; Zulian, Gilbert; Lövblad, Karl-Olof; Giannakopoulos, Panteleimon; Bouras, Constantin

Published inActa neuropathologica communications, vol. 1, no. 1, 14

Publication date2013

Abstract

White matter hyperintensities (WMH) lesions on T2/FLAIR brain MRI are frequently seen in healthy elderly people. Whether these radiological lesions correspond to irreversible histological changes is still a matter of debate. We report the radiologic-histopathologic concordance between T2/FLAIR WMHs and neuropathologically confirmed demyelination in the periventricular, perivascular and deep white matter (WM) areas.

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Citation (ISO format)

HALLER, Sven et al. Do brain T2/FLAIR white matter hyperintensities correspond to myelin loss in normal aging? A radiologic-neuropathologic correlation study. In: Acta neuropathologica communications, 2013, vol. 1, n° 1, p. 14. doi: 10.1186/2051-5960-1-14

Article (Published version)

Identifiers

PID : unige:31357
DOI : 10.1186/2051-5960-1-14
PMID : 24252608

Journal ISSN2051-5960

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Do brain T2/FLAIR white matter hyperintensities correspond to myelin loss in normal aging? A radiologic-neuropathologic correlation study

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