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Design and methodology of the Swiss Transplant Cohort Study (STCS): a comprehensive prospective nationwide long-term follow-up cohort

Müller, Nicolas J.
Marti, Hans-Peter
Fehr, Thomas
Binet, Isabelle
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Published in European journal of epidemiology. 2013, vol. 28, no. 4, p. 347-55
Abstract In Switzerland, organ procurement is well organized at the national-level but transplant outcomes have not been systematically monitored so far. Therefore, a novel project, the Swiss Transplant Cohort Study (STCS), was established. The STCS is a prospective multicentre study, designed as a dynamic cohort, which enrolls all solid organ recipients at the national level. The features of the STCS are a flexible patient-case system that allows capturing all transplant scenarios and collection of patient-specific and allograft-specific data. Beyond comprehensive clinical data, specific focus is directed at psychosocial and behavioral factors, infectious disease development, and bio-banking. Between May 2008 and end of 2011, the six Swiss transplant centers recruited 1,677 patients involving 1,721 transplantations, and a total of 1,800 organs implanted in 15 different transplantation scenarios. 10 % of all patients underwent re-transplantation and 3% had a second transplantation, either in the past or during follow-up. 34% of all kidney allografts originated from living donation. Until the end of 2011 we observed 4,385 infection episodes in our patient population. The STCS showed operative capabilities to collect high-quality data and to adequately reflect the complexity of the post-transplantation process. The STCS represents a promising novel project for comparative effectiveness research in transplantation medicine.
Keywords AdultFemaleGraft SurvivalHumansLongitudinal StudiesMaleMiddle AgedOutcome Assessment (Health Care)Prospective StudiesRegistriesResearch DesignSocioeconomic FactorsSwitzerlandTissue and Organ Procurement/statistics & numerical dataTransplantation/statistics & numerical data
PMID: 23546766
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Article (Published version) (330 Kb) - public document Free access
Research groups Hépatologie chirurgicale (327)
Interfaces Homme-machine en milieu clinique (610)
Quorom-sensing et gènes de virulence (301)
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KOLLER, Michael et al. Design and methodology of the Swiss Transplant Cohort Study (STCS): a comprehensive prospective nationwide long-term follow-up cohort. In: European journal of epidemiology, 2013, vol. 28, n° 4, p. 347-55. doi: 10.1007/s10654-012-9754-y https://archive-ouverte.unige.ch/unige:31188

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Deposited on : 2013-11-20

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