Scientific article
Open access

Design and methodology of the Swiss Transplant Cohort Study (STCS): a comprehensive prospective nationwide long-term follow-up cohort

Published inEuropean journal of epidemiology, vol. 28, no. 4, p. 347-355
Publication date2013

In Switzerland, organ procurement is well organized at the national-level but transplant outcomes have not been systematically monitored so far. Therefore, a novel project, the Swiss Transplant Cohort Study (STCS), was established. The STCS is a prospective multicentre study, designed as a dynamic cohort, which enrolls all solid organ recipients at the national level. The features of the STCS are a flexible patient-case system that allows capturing all transplant scenarios and collection of patient-specific and allograft-specific data. Beyond comprehensive clinical data, specific focus is directed at psychosocial and behavioral factors, infectious disease development, and bio-banking. Between May 2008 and end of 2011, the six Swiss transplant centers recruited 1,677 patients involving 1,721 transplantations, and a total of 1,800 organs implanted in 15 different transplantation scenarios. 10 % of all patients underwent re-transplantation and 3% had a second transplantation, either in the past or during follow-up. 34% of all kidney allografts originated from living donation. Until the end of 2011 we observed 4,385 infection episodes in our patient population. The STCS showed operative capabilities to collect high-quality data and to adequately reflect the complexity of the post-transplantation process. The STCS represents a promising novel project for comparative effectiveness research in transplantation medicine.

  • Adult
  • Female
  • Graft Survival
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Outcome Assessment (Health Care)
  • Prospective Studies
  • Registries
  • Research Design
  • Socioeconomic Factors
  • Switzerland
  • Tissue and Organ Procurement/statistics & numerical data
  • Transplantation/statistics & numerical data
Citation (ISO format)
KOLLER, Michael et al. Design and methodology of the Swiss Transplant Cohort Study (STCS): a comprehensive prospective nationwide long-term follow-up cohort. In: European journal of epidemiology, 2013, vol. 28, n° 4, p. 347–355. doi: 10.1007/s10654-012-9754-y
Main files (1)
Article (Published version)
ISSN of the journal0393-2990

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