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Title

Comparative Study With New Accuracy Metrics for Target Volume Contouring in PET Image Guided Radiation Therapy

Authors
Shepherd, Tony
Teras, Mika
Beichel, Reinhard R.
Boellaard, Ronald
Bruynooghe, Michel
Dicken, Volker
Gooding, Mark J.
Julyan, Peter J.
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Published in IEEE Transactions on Medical Imaging. 2012, vol. 31, no. 11, p. 2006-2024
Abstract The impact of positron emission tomography (PET) on radiation therapy is held back by poor methods of defining functional volumes of interest. Many new software tools are being proposed for contouring target volumes but the different approaches are not adequately compared and their accuracy is poorly evaluated due to the ill-definition of ground truth. This paper compares the largest cohort to date of established, emerging and proposed PET contouring methods, in terms of accuracy and variability. We emphasize spatial accuracy and present a new metric that addresses the lack of unique ground truth. Thirty methods are used at 13 different institutions to contour functional volumes of interest in clinical PET/CT and a custom-built PET phantom representing typical problems in image guided radiotherapy. Contouring methods are grouped according to algorithmic type, level of interactivity and how they exploit structural information in hybrid images. Experiments reveal benefits of high levels of user interaction, as well as simultaneous visualization of CT images and PET gradients to guide interactive procedures. Method-wise evaluation identifies the danger of over-automation and the value of prior knowledge built into an algorithm.
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Research group Imagerie Médicale (TEP et TEMP) (542)
Project FNS: 31003A-135576
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SHEPHERD, Tony et al. Comparative Study With New Accuracy Metrics for Target Volume Contouring in PET Image Guided Radiation Therapy. In: IEEE Transactions on Medical Imaging, 2012, vol. 31, n° 11, p. 2006-2024. https://archive-ouverte.unige.ch/unige:30795

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Deposited on : 2013-10-29

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