Psoriatic arthritis (PsA) is an autoimmune, chronic, systemic inflammatory disorder characterized by the association of arthritis with psoriasis. Patients with PsA may have a heterogeneous and variable clinical course. The condition is complex and multifaceted, with the possibility for prominent involvement in the peripheral and axial diarthrodial joints, the skin and nails, and periarticular structures such as the entheses. Recently, members of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) completed a systematic literature review on psoriatic arthritis. In conjunction with expert opinion and appropriate input from stakeholders, the information from the literature review will serve as the basis for the development of recommendations for the optimal treatment of patients with PsA. As such, these guidelines will form the basis for identifying what constitutes quality medical care for patients with PsA.