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Title

Long-term HIV infection and antiretroviral therapy are associated with bone microstructure alterations in premenopausal women

Authors
Spycher-Elbes, Rachel
Published in Osteoporosis International. 2013, vol. 24, no. 6, p. 1843-1852
Abstract We evaluated the influence of long-term HIV infection and its treatment on distal tibia and radius microstructure. Premenopausal eumenorrheic HIV-positive women displayed trabecular and cortical microstructure alterations, which could contribute to increased bone fragility in those patients. INTRODUCTION: Bone fragility is an emerging issue in HIV-infected patients. Dual-energy X-ray absorptiometry (DXA) quantified areal bone mineral density (BMD) predicts fracture risk, but a significant proportion of fracture risk results from microstructural alterations.
Keywords Absorptiometry, Photon/methodsAdultAnti-HIV Agents/therapeutic useBone Density/physiologyCase-Control StudiesFemaleFemur Neck/physiopathologyHIV Infections/complications/drug therapy/physiopathologyHip Joint/physiopathologyHumansLumbar Vertebrae/physiopathologyMiddle AgedOsteoporosis/physiopathology/virologyOsteoporotic Fractures/etiology/physiopathologyPremenopause/physiologyRadius/physiopathologyRisk FactorsTibia/physiopathologyTomography, X-Ray Computed/methods
Identifiers
PMID: 23138338
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Structures
Research groups Nutrition et os (66)
VIH/SIDA (930)
Groupe Ratib Osman (nouvelles techniques d'imagerie moléculaire) (819)
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(ISO format)
CALMY, Alexandra et al. Long-term HIV infection and antiretroviral therapy are associated with bone microstructure alterations in premenopausal women. In: Osteoporosis International, 2013, vol. 24, n° 6, p. 1843-1852. https://archive-ouverte.unige.ch/unige:28889

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Deposited on : 2013-07-12

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