Long-term HIV infection and antiretroviral therapy are associated with bone microstructure alterations in premenopausal women

Calmy, Alexandra; Chevalley, Thierry; Delhumeau-Cartier, Cécile; Toutous Trellu, Laurence Marie; Spycher-Elbes, Rachel; Ratib, Osman; Zawadynski, Sophie; Rizzoli, René

doi:10.1007/s00198-012-2189-1

Scientific article

English

Long-term HIV infection and antiretroviral therapy are associated with bone microstructure alterations in premenopausal women

ContributorsCalmy, Alexandra

; Chevalley, Thierry

; Delhumeau-Cartier, Cécile; Toutous Trellu, Laurence Marie; Spycher-Elbes, Rachel; Ratib, Osman; Zawadynski, Sophie; Rizzoli, René

Published inOsteoporosis international, vol. 24, no. 6, p. 1843-1852

Collection

Open Access - Licence nationale Springer

Publication date2013

Abstract

We evaluated the influence of long-term HIV infection and its treatment on distal tibia and radius microstructure. Premenopausal eumenorrheic HIV-positive women displayed trabecular and cortical microstructure alterations, which could contribute to increased bone fragility in those patients. INTRODUCTION: Bone fragility is an emerging issue in HIV-infected patients. Dual-energy X-ray absorptiometry (DXA) quantified areal bone mineral density (BMD) predicts fracture risk, but a significant proportion of fracture risk results from microstructural alterations.

Keywords

Absorptiometry, Photon/methods
Adult
Anti-HIV Agents/therapeutic use
Bone Density/physiology
Case-Control Studies
Female
Femur Neck/physiopathology
HIV Infections/complications/drug therapy/physiopathology
Hip Joint/physiopathology
Humans
Lumbar Vertebrae/physiopathology
Middle Aged
Osteoporosis/physiopathology/virology
Osteoporotic Fractures/etiology/physiopathology
Premenopause/physiology
Radius/physiopathology
Risk Factors
Tibia/physiopathology
Tomography, X-Ray Computed/methods

Affiliation entities

Research groups

Citation (ISO format)

CALMY, Alexandra et al. Long-term HIV infection and antiretroviral therapy are associated with bone microstructure alterations in premenopausal women. In: Osteoporosis international, 2013, vol. 24, n° 6, p. 1843–1852. doi: 10.1007/s00198-012-2189-1

Article (Published version)

Identifiers

PID : unige:28889
DOI : 10.1007/s00198-012-2189-1
PMID : 23138338

Journal ISSN0937-941X

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Creation21/06/2013 13:42:00

First validation21/06/2013 13:42:00

Update time14/03/2023 21:20:31

Status update14/03/2023 21:20:31

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Long-term HIV infection and antiretroviral therapy are associated with bone microstructure alterations in premenopausal women

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