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TiNOx coatings increase human primary osteoblasts proliferation independently of the substrate: a short report

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Published in Bio-Medical Materials and Engineering. 2012, vol. 22, no. 5, p. 277-81
Abstract Introduction: When applied onto SLA titanium, Titanium Nitride Oxide (TiNOx) coatings are known for their stimulating effect on osteoblast proliferation while maintaining a high degree of differentiation. Objective: To determine whether the stimulating effect of TiNOx coatings is or is not dependent of the metal substrate.Methods: A TiNOx coating was deposited on roughened stainless steel (SS-SLA-TiNOx). The proliferation and differentiation of human primary osteoblasts were determined and compared to that observed on standard SLA titanium. To this end, cell proliferation and gene expression were monitored for a time course of 3 weeks, with or without additional stimulation by 100 nM 1.25(OH)2 vitamin D3. Results: A 1.5 fold increase in the proliferation rate of cells grown on SS-SLA-TiNOx as compared to Ti-SLA surfaces was observed. A high level of differentiation was also noted. Conclusion: TiNOx coatings yield similar proliferation and differentiation rates when applied onto roughened Ti and SS. This might translate into a more effective osseointegration of endosseous implants made of stronger metals than Ti.
Keywords Alkaline Phosphatase/genetics/metabolismBone Morphogenetic Protein 2/genetics/metabolismCell Differentiation/drug effectsCell Proliferation/drug effectsCoated Materials, Biocompatible/pharmacologyCore Binding Factor Alpha 1 Subunit/genetics/metabolismHumansOsteoblasts/cytology/drug effectsOsteopontin/genetics/metabolismOsteoprotegerin/genetics/metabolismStainless Steel/chemistrySurface PropertiesTitanium/pharmacology
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PMID: 23023144
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Research group Groupe Anselm Wiskott-Susanne Scherrer (315)
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RIEDER, Philippe et al. TiNOx coatings increase human primary osteoblasts proliferation independently of the substrate: a short report. In: Bio-Medical Materials and Engineering, 2012, vol. 22, n° 5, p. 277-81. https://archive-ouverte.unige.ch/unige:28383

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Deposited on : 2013-06-04

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