

Other version: http://www.sciencedirect.com/science/article/pii/S0223523497890812
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A QSAR study confirming the heterogeneity of the HEPT derivatives series regarding their interaction with HIV reverse transcriptase |
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Published in | European Journal of Medicinal Chemistry. 1997, vol. 32, no. 4, p. 279-299 | |
Abstract | QSAR concerning the anti-HIV and cytotoxic activities of a series of HEPT analogues has been established using a Hansch-type approach (TSAR™), a neural network approach (TSAR) and a pharmacophore search method (CATALYST™). The techniques employed allowed reliable activity predictions and confirmed the heterogeneity of this series of compounds, which was previously established in biochemical experiments. | |
Keywords | HEPT — HIV — TSAR — CATALYST — Reverse transcriptase — Neural network | |
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![]() ![]() Other version: http://www.sciencedirect.com/science/article/pii/S0223523497890812 |
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Research group | Groupe Weber | |
Citation (ISO format) | TRONCHET, Jean Marcel Julien et al. A QSAR study confirming the heterogeneity of the HEPT derivatives series regarding their interaction with HIV reverse transcriptase. In: European Journal of Medicinal Chemistry, 1997, vol. 32, n° 4, p. 279-299. doi: 10.1016/S0223-5234(97)89081-2 https://archive-ouverte.unige.ch/unige:2798 |