en
Scientific article
English

A QSAR study confirming the heterogeneity of the HEPT derivatives series regarding their interaction with HIV reverse transcriptase

Published inEuropean journal of medicinal chemistry, vol. 32, no. 4, p. 279-299
Publication date1997
Abstract

QSAR concerning the anti-HIV and cytotoxic activities of a series of HEPT analogues has been established using a Hansch-type approach (TSAR™), a neural network approach (TSAR) and a pharmacophore search method (CATALYST™). The techniques employed allowed reliable activity predictions and confirmed the heterogeneity of this series of compounds, which was previously established in biochemical experiments.

Keywords
  • HEPT
  • HIV
  • TSAR
  • CATALYST
  • Reverse transcriptase
  • Neural network
Research group
Citation (ISO format)
TRONCHET, Jean Marcel Julien et al. A QSAR study confirming the heterogeneity of the HEPT derivatives series regarding their interaction with HIV reverse transcriptase. In: European journal of medicinal chemistry, 1997, vol. 32, n° 4, p. 279–299. doi: 10.1016/S0223-5234(97)89081-2
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0223-5234
494views
1downloads

Technical informations

Creation09/21/2009 4:03:32 PM
First validation09/21/2009 4:03:32 PM
Update time03/14/2023 3:12:01 PM
Status update03/14/2023 3:12:01 PM
Last indexation01/15/2024 6:48:39 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack