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Title

A QSAR study confirming the heterogeneity of the HEPT derivatives series regarding their interaction with HIV reverse transcriptase
Authors
Tronchet, Jean Marcel Julien
Grigorov, Martin
Dolatshahi-Missaghie, Naz
Moriaud, Fabrice
Weber, Jacques
Published in European Journal of Medicinal Chemistry. 1997, vol. 32, no. 4, p. 279-299
Abstract QSAR concerning the anti-HIV and cytotoxic activities of a series of HEPT analogues has been established using a Hansch-type approach (TSAR™), a neural network approach (TSAR) and a pharmacophore search method (CATALYST™). The techniques employed allowed reliable activity predictions and confirmed the heterogeneity of this series of compounds, which was previously established in biochemical experiments.
Keywords HEPT — HIV — TSAR — CATALYST — Reverse transcriptase — Neural network
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Other version: http://www.sciencedirect.com/science/article/pii/S0223523497890812
Structures
Faculté des sciences / Section des sciences pharmaceutiques
Faculté des sciences / Section de chimie et biochimie / Département de chimie physique
Research group Groupe Weber
Citation
(ISO format) 		TRONCHET, Jean Marcel Julien et al. A QSAR study confirming the heterogeneity of the HEPT derivatives series regarding their interaction with HIV reverse transcriptase. In: European Journal of Medicinal Chemistry, 1997, vol. 32, n° 4, p. 279-299. doi: 10.1016/S0223-5234(97)89081-2 https://archive-ouverte.unige.ch/unige:2798

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Deposited on : 2009-09-21

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