A QSAR study confirming the heterogeneity of the HEPT derivatives series regarding their interaction with HIV reverse transcriptase

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Title		A QSAR study confirming the heterogeneity of the HEPT derivatives series regarding their interaction with HIV reverse transcriptase
Authors		Tronchet, Jean M.J. Grigorov, Martin G. Dolatshahi-Missaghieh, Naz Moriaud, Fabrice Weber, Jacques
Published in		European Journal of Medicinal Chemistry. 1997, vol. 32, no. 4, p. 279-299
Abstract		QSAR concerning the anti-HIV and cytotoxic activities of a series of HEPT analogues has been established using a Hansch-type approach (TSAR™), a neural network approach (TSAR) and a pharmacophore search method (CATALYST™). The techniques employed allowed reliable activity predictions and confirmed the heterogeneity of this series of compounds, which was previously established in biochemical experiments.
Keywords		HEPT — HIV — TSAR — CATALYST — Reverse transcriptase — Neural network
Identifiers		DOI: 10.1016/S0223-5234(97)89081-2
Full text		Article (Published version) (1.6 MB) - Limited access to UNIGE Other version: http://www.sciencedirect.com/science/article/pii/S0223523497890812
Structures		Faculté des sciences / Section de chimie et biochimie / Département de chimie physique
Research group		Groupe Weber
Citation (ISO format)		TRONCHET, Jean M.J. et al. A QSAR study confirming the heterogeneity of the HEPT derivatives series regarding their interaction with HIV reverse transcriptase. In: European Journal of Medicinal Chemistry, 1997, vol. 32, n° 4, p. 279-299. https://archive-ouverte.unige.ch/unige:2798

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