Scientific article

Compressibility and compactibility of powdered polymers : poly(vinyl chloride) powders

Published inEuropean journal of pharmaceutics and biopharmaceutics, vol. 44, no. 3, p. 315-322
Publication date1997

The present investigation is concerned with the possible effects of material-related properties (molecular mass, glass transition and melting temperatures, crystallinity, tacticity) and particle-related properties (shape, size, specific surface area) on the compression characteristics of the chosen model polymer powder: poly(vinyl chloride) (PVC). Four grades were selected known in literature for providing compacts of varied mechanical strength. The compression characteristics were determined using an instrumented single-punch tableting machine. The differences in tableting characteristics could not be ascribed to any of the material-related properties, but a direct relationship was observed between the compact strength and the specific surface area of the particles, as measured by nitrogen adsorption. The compact hardness was thus only dependent on the inter- and the intraparticulate contact area, which in turn is dictated by the very peculiar morphology of the grains of the PVC powders, whether prepared by emulsion or suspension polymerization.

  • Polymer
  • Poly(vinyl chloride)
  • Molecular mass
  • Crystallinity
  • Tacticity
  • Morphology
  • Specific surface area
  • Compression characteristics
  • Tableting
Research group
Citation (ISO format)
RIME, Anne-France et al. Compressibility and compactibility of powdered polymers : poly(vinyl chloride) powders. In: European journal of pharmaceutics and biopharmaceutics, 1997, vol. 44, n° 3, p. 315–322. doi: 10.1016/S0939-6411(97)00133-1
Main files (1)
Article (Published version)
ISSN of the journal0939-6411

Technical informations

Creation09/21/2009 4:03:25 PM
First validation09/21/2009 4:03:25 PM
Update time03/14/2023 3:11:58 PM
Status update03/14/2023 3:11:58 PM
Last indexation01/15/2024 6:48:23 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack