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Prostaglandin I(2) analogues enhance already exuberant Th17 cell responses in systemic sclerosis

Allanore, Yannick
Published in Annals of the Rheumatic Diseases. 2012, vol. 71, no. 12, p. 2044-50
Abstract Among pleiotropic effects, the capacity of prostaglandin I(2) (PGI(2)) analogues to affect adaptive immunity remains poorly characterised. The purpose of this study was to assess whether PGI(2) analogues could affect T helper (Th) cell responses in patients with systemic sclerosis (SSc) and healthy donors (HD).
Keywords Adaptive Immunity/drug effects/immunologyAdultAgedAged, 80 and overAntihypertensive Agents/pharmacologyCell Proliferation/drug effectsCells, CulturedCyclic AMP-Dependent Protein Kinases/metabolismEpoprostenol/analogs & derivatives/pharmacologyFemaleHumansIloprost/pharmacologyInterferon-gamma/metabolismInterleukin-17/metabolismInterleukin-23 Subunit p19/metabolismInterleukins/metabolismMaleMiddle AgedMonocytes/drug effects/immunology/metabolismPlatelet Aggregation Inhibitors/pharmacologyScleroderma, Systemic/drug therapy/immunologyTh1 Cells/drug effects/immunology/metabolismTh17 Cells/drug effects/immunology/metabolismYoung Adult
PMID: 22814427
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TRUCHETET, Marie-Elise et al. Prostaglandin I(2) analogues enhance already exuberant Th17 cell responses in systemic sclerosis. In: Annals of the Rheumatic Diseases, 2012, vol. 71, n° 12, p. 2044-50. doi: 10.1136/annrheumdis-2012-201400 https://archive-ouverte.unige.ch/unige:27786

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Deposited on : 2013-05-10

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