Scientific article
Case report

Prostaglandin I(2) analogues enhance already exuberant Th17 cell responses in systemic sclerosis

Published inAnnals of the rheumatic diseases, vol. 71, no. 12, p. 2044-2050
Publication date2012

Among pleiotropic effects, the capacity of prostaglandin I(2) (PGI(2)) analogues to affect adaptive immunity remains poorly characterised. The purpose of this study was to assess whether PGI(2) analogues could affect T helper (Th) cell responses in patients with systemic sclerosis (SSc) and healthy donors (HD).

  • Adaptive Immunity/drug effects/immunology
  • Adult
  • Aged
  • Aged, 80 and over
  • Antihypertensive Agents/pharmacology
  • Cell Proliferation/drug effects
  • Cells, Cultured
  • Cyclic AMP-Dependent Protein Kinases/metabolism
  • Epoprostenol/analogs & derivatives/pharmacology
  • Female
  • Humans
  • Iloprost/pharmacology
  • Interferon-gamma/metabolism
  • Interleukin-17/metabolism
  • Interleukin-23 Subunit p19/metabolism
  • Interleukins/metabolism
  • Male
  • Middle Aged
  • Monocytes/drug effects/immunology/metabolism
  • Platelet Aggregation Inhibitors/pharmacology
  • Scleroderma, Systemic/drug therapy/immunology
  • Th1 Cells/drug effects/immunology/metabolism
  • Th17 Cells/drug effects/immunology/metabolism
  • Young Adult
Citation (ISO format)
TRUCHETET, Marie-Elise et al. Prostaglandin I(2) analogues enhance already exuberant Th17 cell responses in systemic sclerosis. In: Annals of the rheumatic diseases, 2012, vol. 71, n° 12, p. 2044–2050. doi: 10.1136/annrheumdis-2012-201400
Main files (1)
Article (Published version)
ISSN of the journal0003-4967

Technical informations

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