Article (Published version) (467 Kb) - 
Limited access to UNIGE
Highlights
Home
Titles listCopper-Catalyzed Asymmetric Conjugate Addition of Alkenyl- and Alkylalanes to α,β-Unsaturated Lactams
Titles listCopper-Catalyzed Asymmetric Conjugate Addition of Alkenyl- and Alkylalanes to α,β-Unsaturated Lactams
Scientific Article
unige:26461 
 |
Copper-Catalyzed Asymmetric Conjugate Addition of Alkenyl- and Alkylalanes to α,β-Unsaturated Lactams |
|
| Authors | ||
| Published in | Organic letters. 2013, vol. 15, no. 4, p. 828-831 | |
| Abstract | Alkenyl and alkyl groups have been successfully introduced to six-membered α,β-unsaturated lactams via a copper-catalyzed asymmetric 1,4-addition of the corresponding alanes. Moderate to good yields and good to excellent enantioselectivities are achieved by using a combination of the very cheap copper(II) naphthenate and a readily available phosphine amine ligand. The creation of an all-carbon quaternary stereogenic center, via Michael addition to a trisubstituted conjugated lactam, is also disclosed for the first time. | |
| Identifiers | DOI: 10.1021/ol303505k | |
| Full text | ||
| Structures | ||
| Citation (ISO format) | COTTET, Pierre, MUELLER, Daniel, ALEXAKIS, Alexandre. Copper-Catalyzed Asymmetric Conjugate Addition of Alkenyl- and Alkylalanes to α,β-Unsaturated Lactams. In: Organic letters, 2013, vol. 15, n° 4, p. 828-831. doi: 10.1021/ol303505k https://archive-ouverte.unige.ch/unige:26461 |
487 hits 
8 downloads 
Contact an author
Update