UNIGE document Scientific Article
previous document  unige:26461  next document
add to browser collection
Title

Copper-Catalyzed Asymmetric Conjugate Addition of Alkenyl- and Alkylalanes to α,β-Unsaturated Lactams

Authors
Published in Organic Letters. 2013, vol. 15, no. 4, p. 828-831
Abstract Alkenyl and alkyl groups have been successfully introduced to six-membered α,β-unsaturated lactams via a copper-catalyzed asymmetric 1,4-addition of the corresponding alanes. Moderate to good yields and good to excellent enantioselectivities are achieved by using a combination of the very cheap copper(II) naphthenate and a readily available phosphine amine ligand. The creation of an all-carbon quaternary stereogenic center, via Michael addition to a trisubstituted conjugated lactam, is also disclosed for the first time.
Identifiers
Full text
Article (Published version) (467 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Other version: http://pubs.acs.org/doi/abs/10.1021/ol303505k
Structures
Citation
(ISO format)
COTTET, Pierre, MUELLER, Daniel, ALEXAKIS, Alexandre. Copper-Catalyzed Asymmetric Conjugate Addition of Alkenyl- and Alkylalanes to α,β-Unsaturated Lactams. In: Organic Letters, 2013, vol. 15, n° 4, p. 828-831. https://archive-ouverte.unige.ch/unige:26461

193 hits

8 downloads

Update

Deposited on : 2013-02-25

Export document
Format :
Citation style :