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Title

Elevated endocannabinoid plasma levels are associated with coronary circulatory dysfunction in obesity

Authors
Di Marzo, V.
Carballo, S.
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Published in European Heart Journal. 2011, vol. 32, no. 11, p. 1369-1378
Abstract Aims Aim of this study was to evaluate a possible association between endocannabinoid (EC) plasma levels, such as anandamide (AEA) and 2-arachidonoylglycerol (2-AG), and coronary circulatory function in obesity. Methods and results Myocardial blood flow (MBF) responses to cold pressor test (CPT) and during pharmacological vasodilation with dipyridamole were measured with 13N-ammonia PET/CT. Study participants (n ¼ 77) were divided into three groups based on their body mass index (BMI, kg/m2): control group 20≤ BMI ,25 (n ¼ 21); overweight group, 25≤ BMI ,30 (n ¼ 26); and obese group, BMI ≥30 (n ¼ 30). Anandamide plasma levels, but not 2-AG plasma levels, were significantly elevated in obesity as compared with controls, respectively [0.68 (0.53, 0.78) vs. 0.56 (0.47, 0.66) ng/mL, P ¼ 0.020, and 2.2 (1.21, 4.59) vs. 2.0 (0.80, 5.90) ng/mL, P ¼ 0.806)]. The endothelium-related change in MBF during CPT from rest (DMBF) progressively declined in overweight and obese when compared with control group [0.21 (0.10, 0.27) and 0.09 (20.01, 0.15) vs. 0.26 (0.23, 0.39) mL/g/min; P ¼ 0.010 and P ¼ 0.0001, respectively). Compared with controls, hyperaemic MBFs were significantly lower in overweight and obese individuals [2.39 (1.97, 2.62) vs. 1.98 (1.69, 2.26) and 2.10 (1.76, 2.36); P ¼ 0.007 and P ¼ 0.042, respectively)]. In obese individuals, AEA and 2-AG plasma levels were inversely correlated with DMBF to CPT (r ¼ 20.37, P ¼ 0.046 and r ¼ 20.48, P ¼ 0.008) and hyperaemic MBFs (r ¼ 20.38, P ¼ 0.052 and r ¼ 20.45, P ¼ 0.017), respectively. Conclusions Increased EC plasma levels of AEA and 2-AG are associated with coronary circulatory dysfunction in obese individuals. This observation might suggest increases in EC plasma levels as a novel endogenous cardiovascular risk factor in obesity, but needing further investigations.
Keywords Blood flowEndocannabinoidsCirculationCoronary diseaseEndotheliumObesity
Identifiers
PMID: 21303779
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Structures
Research groups Education thérapeutique du patient, diabète et obésité (600)
Toxicologie analytique et forensique (120)
L'athérosclérose et ses complications cliniques (591)
Le rôle du système endocannabinoïde dans l'athérosclérose (882)
Groupe Schindler Thomas (cardiologie) (890)
Cyclotron (897)
Traits génétiques complexes (901)
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(ISO format)
QUERCIOLI, Alessandra et al. Elevated endocannabinoid plasma levels are associated with coronary circulatory dysfunction in obesity. In: European Heart Journal, 2011, vol. 32, n° 11, p. 1369-1378. https://archive-ouverte.unige.ch/unige:25971

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Deposited on : 2013-01-29

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