From unwinding to clamping - the DEAD box RNA helicase family

Linder, Patrick; Jankowsky, Eckhard

doi:10.1038/nrm3154

Scientific article

Meta-analysis

English

From unwinding to clamping - the DEAD box RNA helicase family

Contributors

Linder, Patrick; Jankowsky, Eckhard

Published in

Nature reviews. Molecular cell biology, vol. 12, no. 8, p. 505-516

Publication date

2011

Abstract

RNA helicases of the DEAD box family are present in all eukaryotic cells and in many bacteria and Archaea. These highly conserved enzymes are required for RNA metabolism from transcription to degradation and are therefore important players in gene expression. DEAD box proteins use ATP to unwind short duplex RNA in an unusual fashion and remodel RNA-protein complexes, but they can also function as ATP-dependent RNA clamps to provide nucleation centres that establish larger RNA-protein complexes. Structural, mechanistic and molecular biological studies have started to reveal how these conserved proteins can perform such diverse functions and how accessory proteins have a central role in their regulation.

Keywords

Adenosine Triphosphate/metabolism
Animals
Binding Sites
DEAD-box RNA Helicases/chemistry/genetics/metabolism
Eukaryotic Initiation Factor-4A/metabolism
Humans
Models, Biological
Models, Molecular
Nucleocytoplasmic Transport Proteins/metabolism
Protein Biosynthesis
Protein Structure, Tertiary
RNA, Messenger/chemistry/metabolism
Saccharomyces cerevisiae/metabolism

UNIGE affiliation entities

Faculté de médecine / Section de médecine fondamentale / Département de microbiologie et médecine moléculaire

UNIGE research groups

Acquisition et expression de facteurs de virulence chez Staphylococcus aureus (86)

Citation (ISO format)

LINDER, Patrick, JANKOWSKY, Eckhard. From unwinding to clamping - the DEAD box RNA helicase family. In: Nature reviews. Molecular cell biology, 2011, vol. 12, n° 8, p. 505–516. doi: 10.1038/nrm3154

Article (Published version)

Identifiers

PID : unige:25537
DOI : 10.1038/nrm3154
PMID : 21779027

Journal ISSN

1471-0072

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2633downloads

Creation

06/11/2012 10:40:00

First validation

06/11/2012 10:40:00

Update

14/03/2023 19:57:18

Status update

14/03/2023 19:57:18

Last indexation

30/10/2024 08:27:22

From unwinding to clamping - the DEAD box RNA helicase family

Contributors

Published in

Publication date

Abstract

Keywords

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

Main files (1)

Identifiers

Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation