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From unwinding to clamping - the DEAD box RNA helicase family

Jankowsky, Eckhard
Published in Nature reviews. Molecular cell biology. 2011, vol. 12, no. 8, p. 505-16
Abstract RNA helicases of the DEAD box family are present in all eukaryotic cells and in many bacteria and Archaea. These highly conserved enzymes are required for RNA metabolism from transcription to degradation and are therefore important players in gene expression. DEAD box proteins use ATP to unwind short duplex RNA in an unusual fashion and remodel RNA-protein complexes, but they can also function as ATP-dependent RNA clamps to provide nucleation centres that establish larger RNA-protein complexes. Structural, mechanistic and molecular biological studies have started to reveal how these conserved proteins can perform such diverse functions and how accessory proteins have a central role in their regulation.
Keywords Adenosine Triphosphate/metabolismAnimalsBinding SitesDEAD-box RNA Helicases/chemistry/genetics/metabolismEukaryotic Initiation Factor-4A/metabolismHumansModels, BiologicalModels, MolecularNucleocytoplasmic Transport Proteins/metabolismProtein BiosynthesisProtein Structure, TertiaryRNA, Messenger/chemistry/metabolismSaccharomyces cerevisiae/metabolism
PMID: 21779027
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Research group Acquisition et expression de facteurs de virulence chez Staphylococcus aureus (86)
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LINDER, Patrick, JANKOWSKY, Eckhard. From unwinding to clamping - the DEAD box RNA helicase family. In: Nature reviews. Molecular cell biology, 2011, vol. 12, n° 8, p. 505-16. doi: 10.1038/nrm3154 https://archive-ouverte.unige.ch/unige:25537

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Deposited on : 2013-01-15

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