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Activation of FGF receptors is a new mechanism by which strontium ranelate induces osteoblastic cell growth

Published in Cellular physiology and biochemistry. 2011, vol. 27, no. 3-4, p. 243-50
Abstract Strontium ranelate (SrRan) is an anti-osteoporotic treatment that reduces the risk of vertebral and hip fractures. Recent in vitro studies suggest that the effect of strontium ranelate on osteoblastic cell growth likely involves two processes including activation of the calcium sensing receptor (CaSR) and a yet undefined mechanism. In the present study, we investigated the CaSR-independent molecular mechanism by which SrRan stimulates osteoblast growth.
Keywords AnimalsBone Density Conservation Agents/pharmacologyCell Proliferation/drug effectsCells, CulturedMembrane Proteins/genetics/metabolismMiceMice, Inbred C57BLMitogen-Activated Protein Kinase 1/genetics/metabolismMitogen-Activated Protein Kinase 3/genetics/metabolismOrganometallic Compounds/pharmacologyOsteoblasts/cytology/drug effects/metabolismProto-Oncogene Proteins c-akt/genetics/metabolismReceptors, Calcium-Sensing/agonists/metabolismReceptors, Fibroblast Growth Factor/antagonists & inhibitors/metabolismSignal TransductionThiophenes/pharmacologyP38 Mitogen-Activated Protein Kinases/genetics/metabolism
PMID: 21471713
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Article (Published version) (370 Kb) - public document Free access
Research groups Fonction ostéoblastique (65)
Inflammation et allergie (874)
Swiss National Science Foundation: 310030_127638
(ISO format)
CAVERZASIO, Joseph, THOUVEREY, Cyril. Activation of FGF receptors is a new mechanism by which strontium ranelate induces osteoblastic cell growth. In: Cellular physiology and biochemistry, 2011, vol. 27, n° 3-4, p. 243-50. doi: 10.1159/000327950 https://archive-ouverte.unige.ch/unige:25406

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Deposited on : 2013-01-11

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