Clinical symptoms and alpha band resting-state functional connectivity imaging in patients with schizophrenia: implications for novel approaches to treatment

Hinkley, Leighton B N; Vinogradov, Sophia; Guggisberg, Adrian; Fisher, Melissa; Findlay, Anne M; Nagarajan, Srikantan S

doi:10.1016/j.biopsych.2011.06.029

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Title		Clinical symptoms and alpha band resting-state functional connectivity imaging in patients with schizophrenia: implications for novel approaches to treatment
Authors		Hinkley, Leighton B N Vinogradov, Sophia Guggisberg, Adrian Fisher, Melissa Findlay, Anne M Nagarajan, Srikantan S
Published in		Biological Psychiatry. 2011, vol. 70, no. 12, p. 1134-42
Abstract		Schizophrenia (SZ) is associated with functional decoupling between cortical regions, but we do not know whether and where this occurs in low-frequency electromagnetic oscillations. The goal of this study was to use magnetoencephalography (MEG) to identify brain regions that exhibit abnormal resting-state connectivity in the alpha frequency range in patients with schizophrenia and investigate associations between functional connectivity and clinical symptoms in stable outpatient participants.
Keywords		Adult — Alpha Rhythm/physiology — Case-Control Studies — Cerebral Cortex/physiology/physiopathology — Cortical Synchronization/physiology — Female — Frontal Lobe/physiology/physiopathology — Humans — Magnetoencephalography — Male — Matched-Pair Analysis — Middle Aged — Neural Pathways/physiology/physiopathology — Parietal Lobe/physiology/physiopathology — Reference Values — Schizophrenia/physiopathology — Schizophrenic Psychology — Severity of Illness Index — Temporal Lobe/physiology/physiopathology
Identifiers		DOI: 10.1016/j.biopsych.2011.06.029 PMID: 21861988
Full text		Article (Accepted version) (1.5 MB) - Free access
Structures		Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques
Research group		Neuroréhabilitation assistée par imagerie (910)
Project		Swiss National Science Foundation: 320030_129679
Citation (ISO format)		HINKLEY, Leighton B N et al. Clinical symptoms and alpha band resting-state functional connectivity imaging in patients with schizophrenia: implications for novel approaches to treatment. In: Biological psychiatry, 2011, vol. 70, n° 12, p. 1134-42. doi: 10.1016/j.biopsych.2011.06.029 https://archive-ouverte.unige.ch/unige:25364