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Title

Clinical symptoms and alpha band resting-state functional connectivity imaging in patients with schizophrenia: implications for novel approaches to treatment

Authors
Hinkley, Leighton B N
Vinogradov, Sophia
Fisher, Melissa
Findlay, Anne M
Nagarajan, Srikantan S
Published in Biological Psychiatry. 2011, vol. 70, no. 12, p. 1134-42
Abstract Schizophrenia (SZ) is associated with functional decoupling between cortical regions, but we do not know whether and where this occurs in low-frequency electromagnetic oscillations. The goal of this study was to use magnetoencephalography (MEG) to identify brain regions that exhibit abnormal resting-state connectivity in the alpha frequency range in patients with schizophrenia and investigate associations between functional connectivity and clinical symptoms in stable outpatient participants.
Keywords AdultAlpha Rhythm/physiologyCase-Control StudiesCerebral Cortex/physiology/physiopathologyCortical Synchronization/physiologyFemaleFrontal Lobe/physiology/physiopathologyHumansMagnetoencephalographyMaleMatched-Pair AnalysisMiddle AgedNeural Pathways/physiology/physiopathologyParietal Lobe/physiology/physiopathologyReference ValuesSchizophrenia/physiopathologySchizophrenic PsychologySeverity of Illness IndexTemporal Lobe/physiology/physiopathology
Identifiers
PMID: 21861988
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Article (Author postprint) (1.5 MB) - public document Free access
Structures
Research group Neuroréhabilitation assistée par imagerie (910)
Project FNS: 320030-129679
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HINKLEY, Leighton B N et al. Clinical symptoms and alpha band resting-state functional connectivity imaging in patients with schizophrenia: implications for novel approaches to treatment. In: Biological Psychiatry, 2011, vol. 70, n° 12, p. 1134-42. https://archive-ouverte.unige.ch/unige:25364

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Deposited on : 2013-01-10

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