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Title

Antiplatelet drug response status does not predict recurrent ischemic events in stable cardiovascular patients: results of the Antiplatelet Drug Resistances and Ischemic Events study

Authors
Berdagué, Philippe
Barazer, Isabelle
Fabbro-Peray, Pascale
Schved, Jean-François
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Published in Circulation. 2012, vol. 125, no. 25, p. 3201-10
Abstract The biological response to antiplatelet drugs has repeatedly been shown to predict the recurrence of major adverse cardiovascular events (MACEs). However, most studies involved coronary artery disease patients with recent vessel injury shortly after the initiation of antiplatelet therapy. Data on stable cardiovascular patients are scarce, and the added predictive value of specific assays (the vasodilator phosphoprotein assay for the clopidogrel response and serum thromboxane B2 for the aspirin response) and aggregation-based assays relative to common predictors has rarely been addressed.
Keywords AgedDrug Resistance, Multiple/physiologyFemaleFollow-Up StudiesHumansMaleMiddle AgedMyocardial Ischemia/blood/drug therapy/epidemiologyPlatelet Aggregation/drug effects/physiologyPlatelet Aggregation Inhibitors/blood/therapeutic usePredictive Value of TestsRecurrenceSingle-Blind MethodSurvival Rate/trendsTreatment Outcome
Identifiers
PMID: 22615340
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Structures
Research groups Geneva Platelet Group (13)
Epidémiologie clinique (115)
Citation
(ISO format)
RENY, Jean-Luc et al. Antiplatelet drug response status does not predict recurrent ischemic events in stable cardiovascular patients: results of the Antiplatelet Drug Resistances and Ischemic Events study. In: Circulation, 2012, vol. 125, n° 25, p. 3201-10. https://archive-ouverte.unige.ch/unige:25216

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Deposited on : 2013-01-09

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