UNIGE document Scientific Article
previous document  unige:25209  next document
add to browser collection
Title

Muscle fatigue: from observations in humans to underlying mechanisms studied in intact single muscle fibres

Authors
Yamada, Takashi
Bruton, Joseph D
Westerblad, Håkan
Published in European Journal of Applied Physiology. 2010, vol. 110, no. 1, p. 1-15
Abstract Prolonged dynamic exercise and sustained isometric contractions induce muscle fatigue, as manifested by decreased performance and a reduction in the maximum voluntary contraction force. Studies with non-invasive measurements in exercising humans show that mechanisms located beyond the sarcolemma are important in the fatigue process. In this review, we describe probable cellular mechanisms underlying fatigue-induced changes in excitation-contraction (E-C) coupling occurring in human muscle fibres during strenuous exercise. We use fatigue-induced changes observed in intact single muscle fibres, where force and cellular Ca(2+) handling can be directly measured, to explain changes in E-C coupling observed in human muscle during exercise.
Keywords Excitation Contraction CouplingHumansIsometric ContractionMuscle FatigueMuscle Fibers, Skeletal/metabolism/physiologyMuscle StrengthMuscle, Skeletal/innervation/metabolism/physiologyRecovery of FunctionTime Factors
Identifiers
PMID: 20419312
Full text
Article (Published version) (410 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group Groupe Kayser Bengt (médecine du sport) (306)
Citation
(ISO format)
PLACE, Nicolas et al. Muscle fatigue: from observations in humans to underlying mechanisms studied in intact single muscle fibres. In: European Journal of Applied Physiology, 2010, vol. 110, n° 1, p. 1-15. https://archive-ouverte.unige.ch/unige:25209

196 hits

0 download

Update

Deposited on : 2013-01-09

Export document
Format :
Citation style :