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Scientific article
Open access
English

Muscle fatigue: from observations in humans to underlying mechanisms studied in intact single muscle fibres

Published inEuropean journal of applied physiology, vol. 110, no. 1, p. 1-15
Collection
  • Open Access - Licence nationale Springer
Publication date2010
Abstract

Prolonged dynamic exercise and sustained isometric contractions induce muscle fatigue, as manifested by decreased performance and a reduction in the maximum voluntary contraction force. Studies with non-invasive measurements in exercising humans show that mechanisms located beyond the sarcolemma are important in the fatigue process. In this review, we describe probable cellular mechanisms underlying fatigue-induced changes in excitation-contraction (E-C) coupling occurring in human muscle fibres during strenuous exercise. We use fatigue-induced changes observed in intact single muscle fibres, where force and cellular Ca(2+) handling can be directly measured, to explain changes in E-C coupling observed in human muscle during exercise.

Keywords
  • Excitation Contraction Coupling
  • Humans
  • Isometric Contraction
  • Muscle Fatigue
  • Muscle Fibers, Skeletal/metabolism/physiology
  • Muscle Strength
  • Muscle, Skeletal/innervation/metabolism/physiology
  • Recovery of Function
  • Time Factors
Citation (ISO format)
PLACE, Nicolas et al. Muscle fatigue: from observations in humans to underlying mechanisms studied in intact single muscle fibres. In: European journal of applied physiology, 2010, vol. 110, n° 1, p. 1–15. doi: 10.1007/s00421-010-1480-0
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Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal1439-6319
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531downloads

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