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Studies of circulating microparticle release in peripheral blood after pancreatic islet transplantation

Toti, F
Bayle, F
Egelhofer, H
Richard, M J
Greget, M
Masson, D
Zobairi, F
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Published in Transplantation Proceedings. 2011, vol. 43, no. 9, p. 3241-5
Abstract The loss of graft function after intraportal islet transplantation is likely multifactorial involving allogeneic rejection, recurrent autoimmunity, graft exhaustion due to a marginally implanted islet mass, immunosuppressant toxicity, and impaired β-cell regeneration. Because early markers of the loss of β-cell mass or function are lacking, monitoring of islet function remains a challenging issue. We have reported herein monitoring of membrane procoagulant microparticles (MPs) as markers of cell stress in the plasma of three recipients with various clinical histories. Early kinetics of C-peptide and MPs followed identical patterns during the first weeks after transplantation; a major increase probably reflected processes related to cell infusion and islet engraftment. Importantly in the case of rejection, MPs and C-peptide showed opposite patterns. A fall in C-peptide was associated with enhanced insulin needs. Our results suggested that a peak in MP levels might indicate rejection with prognotic value. Treatment of the loss of islet function by a new islet infusion or steroid therapy returned MP and C-peptide levels to their baselines with concomitant restoration of islet function. In the patient with suspected acute cellular rejection, MPs also appeared to be sensors of immunosuppressive steroid therapy.
PMID: 22099767
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Research group La transplantation d'îlots de Langerhans (623)
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TOTI, F et al. Studies of circulating microparticle release in peripheral blood after pancreatic islet transplantation. In: Transplantation Proceedings, 2011, vol. 43, n° 9, p. 3241-5. https://archive-ouverte.unige.ch/unige:25049

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Deposited on : 2013-01-07

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