Increase of [(18)F]FLT tumor uptake in vivo mediated by FdUrd: toward improving cell proliferation positron emission tomography

Viertl, David; Bischof Delaloye, Angelika; Lanz, Bernard; Poitry-Yamate, Carole; Gruetter, Rolf; Mlynarik, Vladimir; Ametamey, Simon M; Ross, Tobias L; Lehr, Hans-Anton; Andre, Pierre-Alain; Perillo-Adamer, Florence; Kosinski, Marek; Dupertuis, Yves Marc; Buchegger, Franz

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Title		Increase of [(18)F]FLT tumor uptake in vivo mediated by FdUrd: toward improving cell proliferation positron emission tomography
Authors		Viertl, David Bischof Delaloye, Angelika Lanz, Bernard Poitry-Yamate, Carole Gruetter, Rolf Mlynarik, Vladimir Ametamey, Simon M Ross, Tobias L Lehr, Hans-Anton Andre, Pierre-Alain Perillo-Adamer, Florence Kosinski, Marek Dupertuis, Yves Marc Buchegger, Franz show all authors [1 - 14]
Published in		Molecular Imaging and Biology. 2011, vol. 13, no. 2, p. 321-31
Abstract		3'-deoxy-3'-[(18)F]fluorothymidine ([(18)F]FLT), a cell proliferation positron emission tomography (PET) tracer, has been shown in numerous tumors to be more specific than 2-deoxy-2-[(18)F]fluoro-D-glucose ([(18)F]FDG) but less sensitive. We studied the capacity of a nontoxic concentration of 5-fluoro-2'-deoxyuridine (FdUrd), a thymidine synthesis inhibitor, to increase uptake of [(18)F]FLT in tumor xenografts.
Keywords		Animals — Cell Cycle/drug effects — Cell Line, Tumor — Cell Proliferation/drug effects — Dideoxynucleosides/pharmacokinetics/pharmacology — Flow Cytometry — Floxuridine/metabolism/pharmacology — Humans — Magnetic Resonance Imaging — Mice — Neoplasms/metabolism/pathology — Positron-Emission Tomography/methods — Time Factors — Tissue Distribution — Xenograft Model Antitumor Assays
Identifiers		DOI: 10.1007/s11307-010-0368-z PMID: 20556524
Full text		Article (Published version) (913 Kb) - Private access
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine interne des spécialités Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale Faculté de médecine / Section de médecine clinique / Département de gynécologie et d'obstétrique
Research groups		Nutrition clinique (597) Ciblage tumoral par anticorps, peptides et nucléotides radiomarqués (221)
Citation (ISO format)		VIERTL, David et al. Increase of [(18)F]FLT tumor uptake in vivo mediated by FdUrd: toward improving cell proliferation positron emission tomography. In: Molecular Imaging and Biology, 2011, vol. 13, n° 2, p. 321-31. https://archive-ouverte.unige.ch/unige:24426