

![]() |
Increase of [(18)F]FLT tumor uptake in vivo mediated by FdUrd: toward improving cell proliferation positron emission tomography |
|
Authors | ![]() | |
Published in | Molecular imaging and biology. 2011, vol. 13, no. 2, p. 321-31 | |
Abstract | 3'-deoxy-3'-[(18)F]fluorothymidine ([(18)F]FLT), a cell proliferation positron emission tomography (PET) tracer, has been shown in numerous tumors to be more specific than 2-deoxy-2-[(18)F]fluoro-D-glucose ([(18)F]FDG) but less sensitive. We studied the capacity of a nontoxic concentration of 5-fluoro-2'-deoxyuridine (FdUrd), a thymidine synthesis inhibitor, to increase uptake of [(18)F]FLT in tumor xenografts. | |
Keywords | Animals — Cell Cycle/drug effects — Cell Line, Tumor — Cell Proliferation/drug effects — Dideoxynucleosides/pharmacokinetics/pharmacology — Flow Cytometry — Floxuridine/metabolism/pharmacology — Humans — Magnetic Resonance Imaging — Mice — Neoplasms/metabolism/pathology — Positron-Emission Tomography/methods — Time Factors — Tissue Distribution — Xenograft Model Antitumor Assays | |
Identifiers | PMID: 20556524 | |
Full text | ||
Structures | ||
Research groups | Ciblage tumoral par anticorps, peptides et nucléotides radiomarqués (221) Nutrition clinique (597) | |
Citation (ISO format) | VIERTL, David et al. Increase of [(18)F]FLT tumor uptake in vivo mediated by FdUrd: toward improving cell proliferation positron emission tomography. In: Molecular imaging and biology, 2011, vol. 13, n° 2, p. 321-31. doi: 10.1007/s11307-010-0368-z https://archive-ouverte.unige.ch/unige:24426 |