Increase of [(18)F]FLT tumor uptake in vivo mediated by FdUrd: toward improving cell proliferation positron emission tomography

Viertl, David; Bischof Delaloye, Angelika; Lanz, Bernard; Poitry-Yamate, Carole; Gruetter, Rolf; Mlynarik, Vladimir; Ametamey, Simon M; Ross, Tobias L; Lehr, Hans-Anton; Andre, Pierre-Alain; Perillo-Adamer, Florence; Kosinski, Marek; Dupertuis, Yves Marc; Buchegger, Franz

doi:10.1007/s11307-010-0368-z

Scientific article

English

Increase of [(18)F]FLT tumor uptake in vivo mediated by FdUrd: toward improving cell proliferation positron emission tomography

ContributorsViertl, David; Bischof Delaloye, Angelika; Lanz, Bernard; Poitry-Yamate, Carole; Gruetter, Rolf; Mlynarik, Vladimir; Ametamey, Simon M; Ross, Tobias L; Lehr, Hans-Anton; Andre, Pierre-Alain; Perillo-Adamer, Florence; Kosinski, Marek; Dupertuis, Yves Marc

; Buchegger, Franz

Published inMolecular imaging and biology, vol. 13, no. 2, p. 321-331

Publication date2011

Abstract

3'-deoxy-3'-[(18)F]fluorothymidine ([(18)F]FLT), a cell proliferation positron emission tomography (PET) tracer, has been shown in numerous tumors to be more specific than 2-deoxy-2-[(18)F]fluoro-D-glucose ([(18)F]FDG) but less sensitive. We studied the capacity of a nontoxic concentration of 5-fluoro-2'-deoxyuridine (FdUrd), a thymidine synthesis inhibitor, to increase uptake of [(18)F]FLT in tumor xenografts.

Keywords

Animals
Cell Cycle/drug effects
Cell Line, Tumor
Cell Proliferation/drug effects
Dideoxynucleosides/pharmacokinetics/pharmacology
Flow Cytometry
Floxuridine/metabolism/pharmacology
Humans
Magnetic Resonance Imaging
Mice
Neoplasms/metabolism/pathology
Positron-Emission Tomography/methods
Time Factors
Tissue Distribution
Xenograft Model Antitumor Assays

Affiliation

Research group

Citation (ISO format)

VIERTL, David et al. Increase of [(18)F]FLT tumor uptake in vivo mediated by FdUrd: toward improving cell proliferation positron emission tomography. In: Molecular imaging and biology, 2011, vol. 13, n° 2, p. 321–331. doi: 10.1007/s11307-010-0368-z

Article (Published version)

Identifiers

PID : unige:24426
DOI : 10.1007/s11307-010-0368-z
PMID : 20556524

ISSN of the journal1536-1632

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Increase of [(18)F]FLT tumor uptake in vivo mediated by FdUrd: toward improving cell proliferation positron emission tomography

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