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Title

Increase of [(18)F]FLT tumor uptake in vivo mediated by FdUrd: toward improving cell proliferation positron emission tomography

Authors
Viertl, David
Bischof Delaloye, Angelika
Lanz, Bernard
Mlynarik, Vladimir
Ametamey, Simon M
Ross, Tobias L
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Published in Molecular Imaging and Biology. 2011, vol. 13, no. 2, p. 321-31
Abstract 3'-deoxy-3'-[(18)F]fluorothymidine ([(18)F]FLT), a cell proliferation positron emission tomography (PET) tracer, has been shown in numerous tumors to be more specific than 2-deoxy-2-[(18)F]fluoro-D-glucose ([(18)F]FDG) but less sensitive. We studied the capacity of a nontoxic concentration of 5-fluoro-2'-deoxyuridine (FdUrd), a thymidine synthesis inhibitor, to increase uptake of [(18)F]FLT in tumor xenografts.
Keywords AnimalsCell Cycle/drug effectsCell Line, TumorCell Proliferation/drug effectsDideoxynucleosides/pharmacokinetics/pharmacologyFlow CytometryFloxuridine/metabolism/pharmacologyHumansMagnetic Resonance ImagingMiceNeoplasms/metabolism/pathologyPositron-Emission Tomography/methodsTime FactorsTissue DistributionXenograft Model Antitumor Assays
Identifiers
PMID: 20556524
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Article (Published version) (913 Kb) - private document Private access
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Research groups Nutrition clinique (597)
Ciblage tumoral par anticorps, peptides et nucléotides radiomarqués (221)
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VIERTL, David et al. Increase of [(18)F]FLT tumor uptake in vivo mediated by FdUrd: toward improving cell proliferation positron emission tomography. In: Molecular Imaging and Biology, 2011, vol. 13, n° 2, p. 321-31. https://archive-ouverte.unige.ch/unige:24426

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Deposited on : 2012-12-12

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