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Noninvasive imaging techniques in islet transplantation

Published in Current Diabetes Reports. 2011, vol. 11, no. 5, p. 375-83
Collection Open Access - Licence nationale Springer
Abstract Since the Edmonton trials, insulin independence can reproducibly be achieved after islet transplantation. However, a majority of patients resume insulin treatment in the first 5 years after transplantation. Several mechanisms have been proposed but are difficult to pinpoint in one particular patient. Current tools for the metabolic monitoring of islet grafts indicate islet dysfunction when it is too late to take action. Noninvasive imaging of transplanted islets could be used to study β-cell mass and β-cell function just after infusion, during vascularization or autoimmune and alloimmune attacks. This review will focus on the most recent advances in various imaging techniques (bioluminescence imaging, fluorescence optical imaging, MRI, and positron emission tomography). Emphasis will be placed on pertinent approaches for translation to human practice.
Keywords AnimalsDiagnostic Imaging/methodsHumansIslets of Langerhans TransplantationMagnetic Resonance ImagingPositron-Emission Tomography
PMID: 21800023
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Article (Published version) (180 Kb) - public document Free access
Research groups Transplantation et hépatologie (905)
La transplantation d'îlots de Langerhans (623)
Imagerie cardiaque fonctionnelle (541)
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BOROT, Sophie et al. Noninvasive imaging techniques in islet transplantation. In: Current Diabetes Reports, 2011, vol. 11, n° 5, p. 375-83. doi: 10.1007/s11892-011-0215-x https://archive-ouverte.unige.ch/unige:24419

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Deposited on : 2012-12-11

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