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Factors and strategies for improving buccal absorption of peptides

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Published in European Journal of Pharmaceutics and Biopharmaceutics. 2001, vol. 51, no. 2, p. 93-109
Abstract Peptides and polypeptides have important pharmacological properties but only a limited number (e.g. insulin, oxytocin, vasopressin) have been exploited as therapeutics because of problems related to their delivery. The buccal mucosa offers an alternative route to conventional, parenteral administration. Peptides are generally not well absorbed through mucosae because of their molecular size, hydrophilicity and the low permeability of the membrane. Peptide transport across buccal mucosa occurs via passive diffusion and is often accompanied by varying degrees of metabolism. This review describes various approaches to improve the buccal absorption of peptides including the use of penetration enhancers to increase membrane permeability and/or the addition of enzyme inhibitors to increase their stability. Other strategies including molecular modification with bioreversible chemical groups or specific formulations such as bioadhesive delivery systems are also discussed.
Keywords Administration, BuccalAnimalsCell Membrane PermeabilityHumansMouth Mucosa/chemistry/cytology/metabolismPeptides/administration & dosage/chemistry/metabolism/pharmacokinetics
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PMID: 11226816
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VEUILLEZ, Fabienne et al. Factors and strategies for improving buccal absorption of peptides. In: European Journal of Pharmaceutics and Biopharmaceutics, 2001, vol. 51, n° 2, p. 93-109. https://archive-ouverte.unige.ch/unige:21952

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Deposited on : 2012-08-06

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