Scientific article

Factors and strategies for improving buccal absorption of peptides

Published inEuropean journal of pharmaceutics and biopharmaceutics, vol. 51, no. 2, p. 93-109
Publication date2001

Peptides and polypeptides have important pharmacological properties but only a limited number (e.g. insulin, oxytocin, vasopressin) have been exploited as therapeutics because of problems related to their delivery. The buccal mucosa offers an alternative route to conventional, parenteral administration. Peptides are generally not well absorbed through mucosae because of their molecular size, hydrophilicity and the low permeability of the membrane. Peptide transport across buccal mucosa occurs via passive diffusion and is often accompanied by varying degrees of metabolism. This review describes various approaches to improve the buccal absorption of peptides including the use of penetration enhancers to increase membrane permeability and/or the addition of enzyme inhibitors to increase their stability. Other strategies including molecular modification with bioreversible chemical groups or specific formulations such as bioadhesive delivery systems are also discussed.

  • Administration, Buccal
  • Animals
  • Cell Membrane Permeability
  • Humans
  • Mouth Mucosa/chemistry/cytology/metabolism
  • Peptides/administration & dosage/chemistry/metabolism/pharmacokinetics
Citation (ISO format)
VEUILLEZ, Fabienne et al. Factors and strategies for improving buccal absorption of peptides. In: European journal of pharmaceutics and biopharmaceutics, 2001, vol. 51, n° 2, p. 93–109. doi: 10.1016/S0939-6411(00)00144-2
Main files (1)
Article (Published version)
ISSN of the journal0939-6411

Technical informations

Creation07/30/2012 2:40:00 PM
First validation07/30/2012 2:40:00 PM
Update time03/14/2023 5:38:47 PM
Status update03/14/2023 5:38:47 PM
Last indexation05/02/2024 12:35:32 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack