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Vaccine effectiveness in older individuals: what has been learned from the influenza-vaccine experience

Lang, Pierre-Olivier
Govind, Sheila
Mitchell, Wayne A
Aspinall, Richard
Published in Ageing Research Reviews. 2011, vol. 10, no. 3, p. 389-95
Abstract Vaccination policies in most high-income countries attempt to reduce the adverse impact of influenza targeting people aged at least 60 years. However, while it is widely believed that the current immunization strategy saves many lives, influenza infection still remains a severe burden in aged individuals leading to a wide debate on the exact magnitude of the benefit of vaccination in this population. The first aim of the present review is to examine how effective current influenza-vaccine strategies are in aged adults, by analysing which are the most important factors modulating the interpretation of study results in this population. Furthermore, consideration will be given to how immune factors influence the measurement of vaccine efficacy/effectiveness, where advancing age leads to deleterious changes in the adaptive immune system, resulting in less than optimal responses to infectious agents and vaccination. Finally this review concludes with possible strategies to improve the ability of the senescent immune system to respond to vaccination.
Keywords Adaptive Immunity/physiologyAgedAged, 80 and overAging/immunologyHumansInfluenza Vaccines/therapeutic useInfluenza, Human/immunology/prevention & controlTreatment Outcome
PMID: 20888439
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Research group Centre de Vaccinologie et d'Immunologie néonatale (177)
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LANG, Pierre-Olivier et al. Vaccine effectiveness in older individuals: what has been learned from the influenza-vaccine experience. In: Ageing Research Reviews, 2011, vol. 10, n° 3, p. 389-95. doi: 10.1016/j.arr.2010.09.005 https://archive-ouverte.unige.ch/unige:21528

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Deposited on : 2012-06-07

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