UNIGE document Scientific Article
previous document  unige:21384  next document
add to browser collection
Title

Anti-apolipoprotein A-1 IgG predicts major cardiovascular events in patients with rheumatoid arthritis

Authors show hidden authors show all authors [1 - 11]
Published in Arthritis and Rheumatism. 2010, vol. 62, no. 9, p. 2640-2650
Abstract OBJECTIVE: To determine whether anti-apolipoprotein A-1 (anti-Apo A-1) IgG are associated with major cardiovascular events in patients with rheumatoid arthritis (RA). METHODS: We determined anti-Apo A-1 IgG levels and the concentrations of cytokines, oxidized low-density lipoprotein (LDL), and matrix metalloproteinase 1 (MMP-1) MMP-2, MMP-3, and MMP-9 in sera from 133 patients with RA who did not have cardiovascular disease at baseline, all of whom were longitudinally followed up over a median period of 9 years. A major cardiovascular event was defined as a fatal or nonfatal stroke or acute coronary syndrome. The proinflammatory effects of anti-Apo A-1 IgG were assessed on human macrophages in vitro. RESULTS: During followup, the overall incidence of major cardiovascular events was 15% (20 of 133 patients). At baseline, anti-Apo A-1 IgG positivity was 17% and was associated with a higher incidence of major cardiovascular events (adjusted hazard ratio 4.2, 95% confidence interval 1.5-12.1). Patients who experienced a subsequent major cardiovascular event had higher circulating levels of anti-Apo A-1 IgG at baseline compared with those who did not have a major cardiovascular event. Receiver operating curve analysis showed that anti-Apo A-1 IgG was the strongest of all tested biomarkers for the prediction of a subsequent major cardiovascular event, with an area under the curve value of 0.73 (P = 0.0008). At the predefined and previously validated cutoff levels, the specificity and sensitivity of anti-Apo A-1 IgG to predict major cardiovascular events were 50% and 90%, respectively. Anti-Apo A-1 IgG positivity was associated with higher median circulating levels of interleukin-8 (IL-8), oxidized LDL, and MMP-9 and higher proMMP-9 activity as assessed by zymography. On human macrophages, anti-Apo A-1 IgG induced a significant dose-dependent increase in IL-8 and MMP-9 levels and proMMP-9 activity. CONCLUSION: Anti-Apo A-1 IgG is an independent predictor of major cardiovascular events in RA, possibly by affecting vulnerability to atherosclerotic plaque.
Keywords Acute Coronary Syndrome/blood/epidemiology/*immunologyAgedApolipoprotein A-I/*immunologyArthritis, Rheumatoid/blood/epidemiology/*immunologyAutoantibodies/*blood/pharmacologyBiological Markers/bloodCells, CulturedComorbidityCytokines/bloodFemaleHumansImmunoglobulin G/bloodLipoproteins, LDL/bloodLongitudinal StudiesMacrophages/drug effects/metabolismMaleMatrix Metalloproteinases/bloodPredictive Value of TestsStroke/blood/epidemiology/*immunologySwitzerland/epidemiology
Identifiers
PMID: 20506304
Full text
Structures
Research groups Biologie du myocarde (22)
La protéomique au service de la clinique (270)
Mécanisme de l'inflammation articulaire (44)
L'athérosclérose et ses complications cliniques (591)
Interfaces Homme-machine en milieu clinique (610)
Etude de l'activation des monocytes/macrophages et des polynucléaires neutrophiles (779)
Citation
(ISO format)
VUILLEUMIER, Nicolas et al. Anti-apolipoprotein A-1 IgG predicts major cardiovascular events in patients with rheumatoid arthritis. In: Arthritis and Rheumatism, 2010, vol. 62, n° 9, p. 2640-2650. https://archive-ouverte.unige.ch/unige:21384

347 hits

3 downloads

Update

Deposited on : 2012-05-23

Export document
Format :
Citation style :