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Titles listAnti-apolipoprotein A-1 IgG predicts major cardiovascular events in patients with rheumatoid arthritis
Titles listAnti-apolipoprotein A-1 IgG predicts major cardiovascular events in patients with rheumatoid arthritis
Scientific Article
unige:21384 
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Anti-apolipoprotein A-1 IgG predicts major cardiovascular events in patients with rheumatoid arthritis |
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| Published in | Arthritis and rheumatism. 2010, vol. 62, no. 9, p. 2640-2650 | |
| Abstract | OBJECTIVE: To determine whether anti-apolipoprotein A-1 (anti-Apo A-1) IgG are associated with major cardiovascular events in patients with rheumatoid arthritis (RA). METHODS: We determined anti-Apo A-1 IgG levels and the concentrations of cytokines, oxidized low-density lipoprotein (LDL), and matrix metalloproteinase 1 (MMP-1) MMP-2, MMP-3, and MMP-9 in sera from 133 patients with RA who did not have cardiovascular disease at baseline, all of whom were longitudinally followed up over a median period of 9 years. A major cardiovascular event was defined as a fatal or nonfatal stroke or acute coronary syndrome. The proinflammatory effects of anti-Apo A-1 IgG were assessed on human macrophages in vitro. RESULTS: During followup, the overall incidence of major cardiovascular events was 15% (20 of 133 patients). At baseline, anti-Apo A-1 IgG positivity was 17% and was associated with a higher incidence of major cardiovascular events (adjusted hazard ratio 4.2, 95% confidence interval 1.5-12.1). Patients who experienced a subsequent major cardiovascular event had higher circulating levels of anti-Apo A-1 IgG at baseline compared with those who did not have a major cardiovascular event. Receiver operating curve analysis showed that anti-Apo A-1 IgG was the strongest of all tested biomarkers for the prediction of a subsequent major cardiovascular event, with an area under the curve value of 0.73 (P = 0.0008). At the predefined and previously validated cutoff levels, the specificity and sensitivity of anti-Apo A-1 IgG to predict major cardiovascular events were 50% and 90%, respectively. Anti-Apo A-1 IgG positivity was associated with higher median circulating levels of interleukin-8 (IL-8), oxidized LDL, and MMP-9 and higher proMMP-9 activity as assessed by zymography. On human macrophages, anti-Apo A-1 IgG induced a significant dose-dependent increase in IL-8 and MMP-9 levels and proMMP-9 activity. CONCLUSION: Anti-Apo A-1 IgG is an independent predictor of major cardiovascular events in RA, possibly by affecting vulnerability to atherosclerotic plaque. | |
| Keywords | Acute Coronary Syndrome/blood/epidemiology/*immunology — Aged — Apolipoprotein A-I/*immunology — Arthritis, Rheumatoid/blood/epidemiology/*immunology — Autoantibodies/*blood/pharmacology — Biological Markers/blood — Cells, Cultured — Comorbidity — Cytokines/blood — Female — Humans — Immunoglobulin G/blood — Lipoproteins, LDL/blood — Longitudinal Studies — Macrophages/drug effects/metabolism — Male — Matrix Metalloproteinases/blood — Predictive Value of Tests — Stroke/blood/epidemiology/*immunology — Switzerland/epidemiology | |
| Identifiers | DOI: 10.1002/art.27546 PMID: 20506304 | |
| Full text |
Article - Limited access to UNIGE Other version: http://onlinelibrary.wiley.com/store/10.1002/art.27546/asset/27546_ftp.pdf?v=1&t=h1qihx17&s=c7a35754f5dab884da7af63a7... |
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| Structures | ||
| Research groups | Biologie du myocarde (22) Etude de l'activation des monocytes/macrophages et des polynucléaires neutrophiles (779) Interfaces Homme-machine en milieu clinique (610) L'athérosclérose et ses complications cliniques (591) La protéomique au service de la clinique (270) Mécanisme de l'inflammation articulaire (44) | |
| Citation (ISO format) | VUILLEUMIER, Nicolas et al. Anti-apolipoprotein A-1 IgG predicts major cardiovascular events in patients with rheumatoid arthritis. In: Arthritis and rheumatism, 2010, vol. 62, n° 9, p. 2640-2650. doi: 10.1002/art.27546 https://archive-ouverte.unige.ch/unige:21384 |
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