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Title

Preclinical noninvasive markers of atherosclerosis in children and adolescents with type 1 diabetes are influenced by physical activity

Authors
Martin, Xavier E.
Marchand, Laetitia M.
Published in The Journal of Pediatrics. 2010, vol. 157, no. 4, p. 533-539
Abstract OBJECTIVES: To measure preclinical noninvasive markers of atherosclerosis in youth with type 1 diabetes (T1DM), and to determine their associations between physical activity level and cardiorespiratory fitness (maximal oxygen consumption [VO2max]). STUDY DESIGN: This was a cross-sectional study including 32 patients with T1DM and 42 healthy subjects aged 6 to 17 years. Main outcome measures included arterial flow-mediated dilation (FMD) and intima-media thickness with high-resolution ultrasonography; physical activity by accelerometer (valid 26 patients with T1DM, 35 healthy subjects) and VO2max. RESULTS: Compared with healthy control subjects, patients with T1DM had higher intima-media thickness (mean 0.50 mm [0.48-0.52, 95% CI] vs 0.48 [0.47-0.49], P=.02) and reduced FMD (4.9% [4.1%-5.7%] vs 7.3 [6.4-8.1], P=.001), VO2max (45.5 mL/kg/min [43.0-48.0] vs 48.7 [46.7-50.6], P ≤ .001), total (567.1 [458.6-675.6] vs 694.9 [606.6-883.2] counts per minute, P=.001) and moderate-to-vigorous physical activity. Patients with T1DM who did more than 60 min/day(-1) of moderate-to-vigorous physical activity had similar FMD compared with relatively inactive healthy subjects, but not as high as active control subjects. CONCLUSION: Youth with T1DM present early signs of atherosclerosis, as well as low physical activity level and cardiorespiratory fitness. Endothelial function is enhanced in patients who practice more than 60 min/day(-1) of moderate-to-vigorous physical activity.
Keywords AdolescentBiological Markers/bloodChildCoronary Artery Disease/blood/*prevention & control/*ultrasonographyCross-Sectional StudiesDiabetes Mellitus, Type 1/*epidemiologyEndothelium, Vascular/ultrasonographyExerciseFemaleHealth StatusHumansMale*Motor ActivityNitroglycerin/*therapeutic useTunica Intima/pathologyVasodilator Agents/*therapeutic use
Identifiers
PMID: 20826281
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Research group L'hypertension pulmonaire (pédiatrie) (228)
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TRIGONA, Béatrice et al. Preclinical noninvasive markers of atherosclerosis in children and adolescents with type 1 diabetes are influenced by physical activity. In: Journal of Pediatrics, 2010, vol. 157, n° 4, p. 533-539. https://archive-ouverte.unige.ch/unige:21352

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Deposited on : 2012-05-23

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