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Booster vaccination after neonatal priming with acellular pertussis vaccine

Knuf, Markus
Schmitt, Heinz-Josef
Jacquet, Jeanne-Marie
Collard, Alix
Kieninger, Dorothee
Meyer, Claudius U.
Zepp, Fred
Published in Journal of Pediatrics. 2010, vol. 156, no. 4, p. 675-678
Abstract After a birth dose of acellular pertussis (aP) and diphtheria (DT)aP-hepatitis B virus (HBV)-inactivated polio vaccine (IPV)/Haemophilus influenza type b (Hib) at 2, 4, and 6 months, a booster dose of DTaP-HBV-IPV/Hib at 12 to 23 months induced strong anti-pertussis booster responses. Thus, neonatal aP priming did not lead to immune tolerance to pertussis antigens. However, it elicited bystander interference on HBV, Hib, and diphtheria responses.
Keywords Dose-Response Relationship, DrugFollow-Up StudiesHumansImmunization, Secondary/*methodsInfantInfant, NewbornPertussis Vaccine/*administration & dosagePrognosisVaccination/*methodsVaccines, AcellularWhooping Cough/*prevention & control
PMID: 20303444
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Research group Centre de Vaccinologie et d'Immunologie néonatale (177)
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KNUF, Markus et al. Booster vaccination after neonatal priming with acellular pertussis vaccine. In: Journal of Pediatrics, 2010, vol. 156, n° 4, p. 675-678. https://archive-ouverte.unige.ch/unige:21047

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Deposited on : 2012-05-23

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