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Scientific article
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English

Booster vaccination after neonatal priming with acellular pertussis vaccine

ContributorsKnuf, Markus; Schmitt, Heinz-Josef; Jacquet, Jeanne-Marie; Collard, Alix; Kieninger, Dorothee; Meyer, Claudius U.; Siegrist, Claire-Anne; Zepp, Fred
Published inThe Journal of pediatrics, vol. 156, no. 4, p. 675-678
Publication date2010
Abstract

After a birth dose of acellular pertussis (aP) and diphtheria (DT)aP-hepatitis B virus (HBV)-inactivated polio vaccine (IPV)/Haemophilus influenza type b (Hib) at 2, 4, and 6 months, a booster dose of DTaP-HBV-IPV/Hib at 12 to 23 months induced strong anti-pertussis booster responses. Thus, neonatal aP priming did not lead to immune tolerance to pertussis antigens. However, it elicited bystander interference on HBV, Hib, and diphtheria responses.

Keywords
  • Dose-Response Relationship, Drug
  • Follow-Up Studies
  • Humans
  • Immunization, Secondary/*methods
  • Infant
  • Infant, Newborn
  • Pertussis Vaccine/*administration & dosage
  • Prognosis
  • Vaccination/*methods
  • Vaccines, Acellular
  • Whooping Cough/*prevention & control
Affiliation entities
Research groups
Citation (ISO format)
KNUF, Markus et al. Booster vaccination after neonatal priming with acellular pertussis vaccine. In: The Journal of pediatrics, 2010, vol. 156, n° 4, p. 675–678. doi: 10.1016/j.jpeds.2009.12.019
Main files (1)
Article
accessLevelRestricted
Identifiers
Journal ISSN0022-3476
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