en
Scientific article
English

Peripheral ghrelin enhances sweet taste food consumption and preference, regardless of its caloric content

Published inPhysiology & behavior, vol. 101, no. 2, p. 277-281
Publication date2010
Abstract

AIMS: Ghrelin is one of the most potent orexigens known to date. While the prevailing view is that ghrelin participates in the homeostatic control of feeding, the question arose as to whether consummatory responses evoked by this compound could be related to search for reward. We therefore attempted to delineate the involvement of ghrelin in the modulation of non-caloric but highly rewarding consumption. METHODS: We tested the effect of intraperitoneally injected ghrelin on the acceptance and preference for a 0.3% saccharin solution using single bottle tests and free-choice preference test procedures in C57BL6/J mice, as well as in mice lacking the ghrelin receptor (GHSR1a -/-) and their wild-type (WT) littermates. RESULTS: In the single bottle tests, peripheral ghrelin consistently increased the consumption of saccharin, independently of availability of caloric food. In the free-choice preference test procedures, ghrelin increased the preference for saccharin in WT mice, while it did had not effect in GHSR1a -/-animals, indicating that the ghrelin receptor pathway is necessary to mediate this parameter. CONCLUSIONS: Peripheral ghrelin enhances intake and preference for a sweet food, regardless of whether the food has caloric content. This effect, mediated through the ghrelin receptor pathway, may serve as additional enhancers of energy intake.

Keywords
  • Analysis of Variance
  • Animals
  • Choice Behavior/drug effects
  • Eating/*drug effects/genetics
  • Energy Intake/*drug effects/genetics
  • Food Preferences/*drug effects
  • Ghrelin/*administration & dosage
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Receptors, Ghrelin/deficiency
  • Saccharin/administration & dosage/*pharmacology
  • Sweetening Agents/administration & dosage/*pharmacology
  • Taste/*drug effects/genetics
Citation (ISO format)
DISSE, Emmanuel et al. Peripheral ghrelin enhances sweet taste food consumption and preference, regardless of its caloric content. In: Physiology & behavior, 2010, vol. 101, n° 2, p. 277–281. doi: 10.1016/j.physbeh.2010.05.017
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ISSN of the journal0031-9384
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