Glycoconjugate vaccines and immune interference: A review

Dagan, Ron; Poolman, Jan; Siegrist, Claire-Anne

doi:10.1016/j.vaccine.2010.06.026

Scientific article

Review

English

Glycoconjugate vaccines and immune interference: A review

Contributors

Dagan, Ron; Poolman, Jan; Siegrist, Claire-Anne

Published in

Vaccine, vol. 28, no. 34, p. 5513-5523

Publication date

2010

Abstract

Bacterial polysaccharide-protein conjugate vaccines (Haemophilus influenzae type b [Hib], pneumococcal and meningococcal conjugates) have revolutionized pediatric vaccination strategies. The widely used carrier proteins are tetanus toxoid (TT), diphtheria toxoid (DT) and diphtheria toxoid variant CRM197 protein, DT conjugates being in general less immunogenic. Multivalent conjugates using TT were found to be at risk for reduced polysaccharide responses, whilst multivalent CRM197 conjugates are at lower risk for this, but may be at higher risk of inducing bystander interference, particularly affecting Hib and hepatitis B immune responses. Novel carriers avoiding these issues could enable the further development of pediatric schedules and combinations.

Keywords

Bacterial Proteins/*immunology
Bacterial Vaccines/*immunology
Diphtheria Toxoid/immunology
Epitopes/immunology
Polysaccharides, Bacterial/*immunology
T-Lymphocytes/immunology
Tetanus Toxoid/immunology
Vaccines, Conjugate/immunology

UNIGE affiliation entities

Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

UNIGE research groups

Centre de Vaccinologie et d'Immunologie néonatale (177)

Citation (ISO format)

DAGAN, Ron, POOLMAN, Jan, SIEGRIST, Claire-Anne. Glycoconjugate vaccines and immune interference: A review. In: Vaccine, 2010, vol. 28, n° 34, p. 5513–5523. doi: 10.1016/j.vaccine.2010.06.026

Article

Identifiers

PID : unige:20868
DOI : 10.1016/j.vaccine.2010.06.026
PMID : 20600514

Additional URL for this publication

http://ac.els-cdn.com/S0264410X10008261/1-s2.0-S0264410X10008261-main.pdf?_tid=2075ac4e2ad861b7e97df2aaf7bb33aa&acdnat=1335966507_4d5732132b20d5f586c15b7d1b7212b6

Journal ISSN

0264-410X

570views

0downloads

Creation

23/05/2012 08:44:59

First validation

23/05/2012 08:44:59

Update

14/03/2023 17:32:30

Status update

14/03/2023 17:32:30

Last indexation

29/10/2024 19:58:15

Glycoconjugate vaccines and immune interference: A review

Contributors

Published in

Publication date

Abstract

Keywords

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

Main files (1)

Identifiers

Additional URL for this publication

Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation