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Diagnosis of venous thromboembolism: an update

Published in Vascular Medicine. 2010, vol. 15, no. 5, p. 399-406
Abstract Deep vein thrombosis (DVT) and pulmonary embolism (PE) cannot be diagnosed solely on a clinical basis owing to the lack of sensitivity and specificity of clinical signs and symptoms. Phlebography and pulmonary angiography are invasive and resource-demanding imaging modalities. Because the prevalence of DVT and PE is relatively low (typically 20% or less) among clinically suspected individuals, submitting all of them to imaging would not be cost-effective. Therefore, non-invasive diagnostic algorithms have been developed that include clinical probability assessment and D-dimer measurement. These initial steps allow the selection of patients who require non-invasive imaging: compression ultrasonography in cases of suspected DVT and multidetector computed tomography (CT) angiography in cases of suspected PE. This review gives a critical appraisal of the sequential steps of the diagnostic work-up in suspected DVT or PE.
Keywords Age FactorsAlgorithmsBiological Markers/bloodFibrin Fibrinogen Degradation Products/analysisHumansMagnetic Resonance AngiographyPredictive Value of TestsPrognosisPulmonary Embolism/*diagnosis/therapyRisk AssessmentRisk FactorsTomography, X-Ray ComputedUltrasonographyVenous Thromboembolism/*diagnosis/therapyVenous Thrombosis/*diagnosis/therapy
PMID: 20926499
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Other version: http://vmj.sagepub.com/content/15/5/399.full.pdf
Research groups Geneva Platelet Group (13)
Groupe Perrier Arnaud (Médecine interne générale, de réhabilitation et de gériatrie) (585)
La maladie thromboembolique veineuse (808)
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BOUNAMEAUX, Henri, PERRIER, Arnaud, RIGHINI, Marc Philip. Diagnosis of venous thromboembolism: an update. In: Vascular Medicine, 2010, vol. 15, n° 5, p. 399-406. https://archive-ouverte.unige.ch/unige:20796

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Deposited on : 2012-05-23

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