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Abnormal cortical network activation in human amnesia: A high-resolution evoked potential study

Bindschaedler, Claire
Published in Brain topography. 2010, vol. 23, no. 1, p. 72-81
Collection Open Access - Licence nationale Springer
Abstract Little is known about how human amnesia affects the activation of cortical networks during memory processing. In this study, we recorded high-density evoked potentials in 12 healthy control subjects and 11 amnesic patients with various types of brain damage affecting the medial temporal lobes, diencephalic structures, or both. Subjects performed a continuous recognition task composed of meaningful designs. Using whole-scalp spatiotemporal mapping techniques, we found that, during the first 200 ms following picture presentation, map configuration of amnesics and controls were indistinguishable. Beyond this period, processing significantly differed. Between 200 and 350 ms, amnesic patients expressed different topographical maps than controls in response to new and repeated pictures. From 350 to 550 ms, healthy subjects showed modulation of the same maps in response to new and repeated items. In amnesics, by contrast, presentation of repeated items induced different maps, indicating distinct cortical processing of new and old information. The study indicates that cortical mechanisms underlying memory formation and re-activation in amnesia fundamentally differ from normal memory processing.
Keywords Amnesia/etiology/*physiopathologyBrain/*physiopathologyBrain Injuries/complications/physiopathologyBrain MappingDiencephalon/injuries/physiopathologyElectroencephalographyEvoked PotentialsFemaleHumansMaleMiddle AgedNeural Pathways/physiologyNeuropsychological TestsPhotic StimulationRecognition (Psychology)/*physiologyTemporal Lobe/injuries/physiopathologyTime FactorsVisual Perception/physiology
PMID: 19960364
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Research group Amnésie (289)
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BARCELLONA-LEHMANN, Sandra et al. Abnormal cortical network activation in human amnesia: A high-resolution evoked potential study. In: Brain topography, 2010, vol. 23, n° 1, p. 72-81. doi: 10.1007/s10548-009-0124-3 https://archive-ouverte.unige.ch/unige:20759

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Deposited on : 2012-05-23

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