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Scientific article
Open access
English

Abnormal cortical network activation in human amnesia: A high-resolution evoked potential study

Published inBrain topography, vol. 23, no. 1, p. 72-81
Collection
  • Open Access - Licence nationale Springer
Publication date2010
Abstract

Little is known about how human amnesia affects the activation of cortical networks during memory processing. In this study, we recorded high-density evoked potentials in 12 healthy control subjects and 11 amnesic patients with various types of brain damage affecting the medial temporal lobes, diencephalic structures, or both. Subjects performed a continuous recognition task composed of meaningful designs. Using whole-scalp spatiotemporal mapping techniques, we found that, during the first 200 ms following picture presentation, map configuration of amnesics and controls were indistinguishable. Beyond this period, processing significantly differed. Between 200 and 350 ms, amnesic patients expressed different topographical maps than controls in response to new and repeated pictures. From 350 to 550 ms, healthy subjects showed modulation of the same maps in response to new and repeated items. In amnesics, by contrast, presentation of repeated items induced different maps, indicating distinct cortical processing of new and old information. The study indicates that cortical mechanisms underlying memory formation and re-activation in amnesia fundamentally differ from normal memory processing.

Keywords
  • Amnesia/etiology/*physiopathology
  • Brain/*physiopathology
  • Brain Injuries/complications/physiopathology
  • Brain Mapping
  • Diencephalon/injuries/physiopathology
  • Electroencephalography
  • Evoked Potentials
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neural Pathways/physiology
  • Neuropsychological Tests
  • Photic Stimulation
  • Recognition (Psychology)/*physiology
  • Temporal Lobe/injuries/physiopathology
  • Time Factors
  • Visual Perception/physiology
Research group
Citation (ISO format)
BARCELLONA-LEHMANN, Sandra et al. Abnormal cortical network activation in human amnesia: A high-resolution evoked potential study. In: Brain topography, 2010, vol. 23, n° 1, p. 72–81. doi: 10.1007/s10548-009-0124-3
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Article (Published version)
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Identifiers
ISSN of the journal0896-0267
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203downloads

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