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Scientific article
English

Donor pancreata: evolving approaches to organ allocation for whole pancreas versus islet transplantation

Contributors

Berney, Thierry; Johnson, Paul R. V.

Published in

Transplantation, vol. 90, no. 3, p. 238-243

Publication date

2010

Abstract

As islet transplantation increasingly enters the clinical arena, its coexistence with vascularized pancreas transplantation makes it necessary to reassess the questions of donor selection and allocation. In answering these questions, one must put in the balance the short-term morbidity of pancreas transplantation with the long-term attrition of islet grafts. The preferential allocation of pancreases from obese and older donors for islet isolation has been based on their association with worse pancreas transplant outcomes and better islet isolation results in islet yields. In this overview, we show that transplanted islet mass does not necessarily correlate with graft function and make the case that donor selection criteria for islet transplantation, and hence allocation rules, may need to be redefined.

Keywords

  • Age Factors
  • Body Mass Index
  • Donor Selection
  • Graft Survival
  • Health Care Rationing
  • Humans
  • Islets of Langerhans Transplantation/adverse effects
  • Pancreas Transplantation/adverse effects
  • Practice Guidelines as Topic
  • Quality of Health Care
  • Risk Assessment
  • Risk Factors
  • Time Factors
  • Tissue Donors/ supply & distribution
  • Tissue and Organ Procurement
  • Treatment Outcome

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

BERNEY, Thierry, JOHNSON, Paul R. V. Donor pancreata: evolving approaches to organ allocation for whole pancreas versus islet transplantation. In: Transplantation, 2010, vol. 90, n° 3, p. 238–243. doi: 10.1097/TP.0b013e3181e25a40

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Additional URL for this publication

http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=toc&SEARCH=00007890-201102150-00000.kc&LINKTYPE=asBody&LINKPOS=1&D=ovft

Journal ISSN

0041-1337
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Technical informations

Creation

23/05/2012 08:43:41

First validation

23/05/2012 08:43:41

Update

14/03/2023 17:31:00

Status update

14/03/2023 17:31:00

Last indexation

29/10/2024 19:53:17
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