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Donor pancreata: evolving approaches to organ allocation for whole pancreas versus islet transplantation

Johnson, Paul R. V.
Published in Transplantation. 2010, vol. 90, no. 3, p. 238-243
Abstract As islet transplantation increasingly enters the clinical arena, its coexistence with vascularized pancreas transplantation makes it necessary to reassess the questions of donor selection and allocation. In answering these questions, one must put in the balance the short-term morbidity of pancreas transplantation with the long-term attrition of islet grafts. The preferential allocation of pancreases from obese and older donors for islet isolation has been based on their association with worse pancreas transplant outcomes and better islet isolation results in islet yields. In this overview, we show that transplanted islet mass does not necessarily correlate with graft function and make the case that donor selection criteria for islet transplantation, and hence allocation rules, may need to be redefined.
Keywords Age FactorsBody Mass IndexDonor SelectionGraft SurvivalHealth Care RationingHumansIslets of Langerhans Transplantation/adverse effectsPancreas Transplantation/adverse effectsPractice Guidelines as TopicQuality of Health CareRisk AssessmentRisk FactorsTime FactorsTissue Donors/ supply & distributionTissue and Organ ProcurementTreatment Outcome
PMID: 20463635
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Research group La transplantation d'îlots de Langerhans (623)
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BERNEY, Thierry, JOHNSON, Paul R. V. Donor pancreata: evolving approaches to organ allocation for whole pancreas versus islet transplantation. In: Transplantation, 2010, vol. 90, n° 3, p. 238-243. doi: 10.1097/TP.0b013e3181e25a40 https://archive-ouverte.unige.ch/unige:20673

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Deposited on : 2012-05-23

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