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Scientific article
English

The interplay between BCL-2 family proteins and mitochondrial morphology in the regulation of apoptosis

Published inAdvances in experimental medicine and biology, vol. 687, p. 97-114
Publication date2010
Abstract

Apoptosis is a highly regulated process where key players such as BCL-2 family members control the recruitment of the mitochondrial subroutine. This culminates in the release of cytochrome c from the organelle in the cytoplasm, where it is required for the activation of effector caspases. The complete release of cytochrome c is the result of the combined action of proapoptotic BCL-2 family members and of changes in the complex morphology and ultrastructure of the organelle, controlled by the balance between fusion and fission processes. Here we discuss recent findings pointing to a role for changes in mitochondrial morphology during apoptosis and how these might be regulated by members of the BCL-2 family.

Keywords
  • Animals
  • Apoptosis/*physiology
  • History, 20th Century
  • Humans
  • Mitochondria/metabolism/*ultrastructure
  • Proto-Oncogene Proteins c-bcl-2/genetics/*metabolism
  • Signal Transduction/physiology
  • Bcl-X Protein/genetics/metabolism
Citation (ISO format)
SORIANO, Maria Eugenia, SCORRANO, Luca. The interplay between BCL-2 family proteins and mitochondrial morphology in the regulation of apoptosis. In: Advances in experimental medicine and biology, 2010, vol. 687, p. 97–114.
Identifiers
ISSN of the journal0065-2598
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