The interplay between BCL-2 family proteins and mitochondrial morphology in the regulation of apoptosis
|Published in||Advances in Experimental Medicine and Biology. 2010, vol. 687, p. 97-114|
|Abstract||Apoptosis is a highly regulated process where key players such as BCL-2 family members control the recruitment of the mitochondrial subroutine. This culminates in the release of cytochrome c from the organelle in the cytoplasm, where it is required for the activation of effector caspases. The complete release of cytochrome c is the result of the combined action of proapoptotic BCL-2 family members and of changes in the complex morphology and ultrastructure of the organelle, controlled by the balance between fusion and fission processes. Here we discuss recent findings pointing to a role for changes in mitochondrial morphology during apoptosis and how these might be regulated by members of the BCL-2 family.|
|Keywords||Animals — Apoptosis/*physiology — History, 20th Century — Humans — Mitochondria/metabolism/*ultrastructure — Proto-Oncogene Proteins c-bcl-2/genetics/*metabolism — Signal Transduction/physiology — Bcl-X Protein/genetics/metabolism|
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|Research group||Les mitochondries dans la vie cellulaire (850)|
|SORIANO, Maria Eugenia, SCORRANO, Luca. The interplay between BCL-2 family proteins and mitochondrial morphology in the regulation of apoptosis. In: Advances in Experimental Medicine and Biology, 2010, vol. 687, p. 97-114. https://archive-ouverte.unige.ch/unige:20566|