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Differences in heart rate variability associated with long-term exposure to NO2

Felber Dietrich, Denise
Gemperli, Armin
Schindler, Christian
Liu, L-J Sally
Gold, Diane R.
Schwartz, Joel
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Published in Environmental health perspectives. 2008, vol. 116, no. 10, p. 1357-61
Abstract BACKGROUND: Heart rate variability (HRV), a measure of cardiac autonomic tone, has been associated with cardiovascular morbidity and mortality. Short-term studies have shown that subjects exposed to higher traffic-associated air pollutant levels have lower HRV. OBJECTIVE: Our objective was to investigate the effect of long-term exposure to nitrogen dioxide on HRV in the Swiss cohort Study on Air Pollution and Lung Diseases in Adults (SAPALDIA). METHODS: We recorded 24-hr electrocardiograms in randomly selected SAPALDIA participants >or= 50 years of age. Other examinations included an interview investigating health status and measurements of blood pressure, body height, and weight. Annual exposure to NO2 at the address of residence was predicted by hybrid models (i.e., a combination of dispersion predictions, land-use, and meteorologic parameters). We estimated the association between NO2 and HRV in multivariable linear regression models. Complete data for analyses were available for 1,408 subjects. RESULTS: For women, but not for men, each 10-microg/m3 increment in 1-year averaged NO2 level was associated with a decrement of 3% (95% CI, -4 to -1) for the standard deviation of all normal-to-normal RR intervals (SDNN), -6% (95% CI, -11 to -1) for nighttime low frequency (LF), and -5% (95% CI, -9 to 0) for nighttime LF/high-frequency (HF) ratio. We saw no significant effect for 24-hr total power (TP), HF, LF, or LF/HF or for nighttime SDNN, TP, or HF. In subjects with self-reported cardiovascular problems, SDNN decreased by 4% (95% CI, -8 to -1) per 10-microg/m3 increase in NO2. CONCLUSIONS: There is some evidence that long-term exposure to NO2 is associated with cardiac autonomic dysfunction in elderly women and in subjects with cardiovascular disease.
Keywords AdultAir Pollutants/toxicityCohort StudiesElectrocardiographyFemaleHeart Rate/drug effectsHumansMaleNitrogen Dioxide/toxicity
PMID: 18941578
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Research groups SAPALDIA Team
Groupe Jean-Michel Gaspoz (23)
L'épithélium respiratoire (852)
Monitoring du programme d'études et de formation pré-graduée de médecine (877)
Pneumologie Clinique (576)
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FELBER DIETRICH, Denise et al. Differences in heart rate variability associated with long-term exposure to NO2. In: Environmental health perspectives, 2008, vol. 116, n° 10, p. 1357-61. doi: 10.1289/ehp.11377 https://archive-ouverte.unige.ch/unige:2056

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Deposited on : 2009-06-16

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