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Atteintes médicamenteuses du tractus gastro-intestinal: une revue clinico-pathologique

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Published in Revue médicale suisse. 2010, vol. 6, no. 261, p. 1650-1655
Abstract Many drugs are known to have adverse effects on the gastrointestinal tract. The consequences can range from asymptomatic histological lesions in the gastrointestinal mucosa to fatal complications such as haemorrhage or perforation. On the biopsies (or on surgical specimens), there is a limited number of injury pattern that should suggest drug-induced pathology. They are mostly non specific (ex: ulcer). However, some drugs may induce pathognomonic histological lesions. For this reason, the diagnosis of a drug-induced gastrointestinal pathology depends on a clinicopathological correlation and implies a good communication between the pathologist and the clinician. In this review, we focus on the most common and well-described drug-related clinico-pathological conditions of the gastrointestinal tract using an organ and lesion based approach.
Keywords Apoptosis/drug effectsColitis/chemically induced/pathologyDuodenal Ulcer/chemically induced/pathologyEosinophilsEsophagitis/chemically induced/pathologyGastrointestinal Diseases/*chemically induced/*pathologyGastrointestinal Tract/*drug effects/*pathologyHumansIntestinal Mucosa/drug effects/pathologySeverity of Illness IndexStomach Ulcer/chemically induced/pathology
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PMID: 20939398
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Structures
Research group Métastases du foie (657)
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PUSZTASZERI, Marc et al. Atteintes médicamenteuses du tractus gastro-intestinal: une revue clinico-pathologique. In: Revue médicale suisse, 2010, vol. 6, n° 261, p. 1650-1655. https://archive-ouverte.unige.ch/unige:20550

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Deposited on : 2012-05-22

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