UNIGE document Scientific Article
previous document  unige:20510  next document
add to browser collection
Title

Role of mitochondria in beta-cell function and dysfunction

Authors
Published in Myosins : a superfamily of melecular motors. 2010, vol. 654, p. 193-216
Abstract Pancreatic beta-cells are poised to sense glucose and other nutrient secretagogues to regulate insulin exocytosis, thereby maintaining glucose homeostasis. This process requires translation of metabolic substrates into intracellular messengers recognized by the exocytotic machinery. Central to this metabolism-secretion coupling, mitochondria integrate and generate metabolic signals, thereby connecting glucose recognition to insulin exocytosis. In response to a glucose rise, nucleotides and metabolites are generated by mitochondria and participate, together with cytosolic calcium, to the stimulation of insulin release. This review describes the mitochondrion-dependent pathways of regulated insulin secretion. Mitochondrial defects, such as mutations and reactive oxygen species production, are discussed in the context of beta-cell failure that may participate to the etiology of diabetes.
Keywords Adenosine Triphosphate/metabolismAnimalsDiabetes Mellitus/*metabolismFatty Acids/metabolismGlucose/metabolismGlutamate Dehydrogenase/metabolismGlutamic Acid/metabolismHumansInsulin/secretionInsulin-Secreting Cells/*cytologyMitochondria/metabolism/*physiologyModels, BiologicalNAD/metabolismReactive Oxygen Species
Identifiers
PMID: 20217499
Full text
Structures
Research group Mitochondries et sécrétion d'insuline (671)
Citation
(ISO format)
MAECHLER, Pierre et al. Role of mitochondria in beta-cell function and dysfunction. In: Advances in Experimental Medicine and Biology, 2010, vol. 654, p. 193-216. doi: 10.1007/978-90-481-3271-3_9 https://archive-ouverte.unige.ch/unige:20510

376 hits

0 download

Update

Deposited on : 2012-05-22

Export document
Format :
Citation style :