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Current status of xenotransplantation and prospects for clinical application

Pierson, Richard N 3rd
Dorling, Anthony
Ayares, David
Rees, Michael A.
Fishman, Jay A.
Hering, Bernhard J.
Cooper, David K. C.
Published in Xenotransplantation. 2009, vol. 16, no. 5, p. 263-280
Abstract Xenotransplantation is one promising approach to bridge the gap between available human cells, tissues, and organs and the needs of patients with diabetes or end-stage organ failure. Based on recent progress using genetically modified source pigs, improving results with conventional and experimental immunosuppression, and expanded understanding of residual physiologic hurdles, xenotransplantation appears likely to be evaluated in clinical trials in the near future for some select applications. This review offers a comprehensive overview of known mechanisms of xenograft injury, a contemporary assessment of preclinical progress and residual barriers, and our opinions regarding where breakthroughs are likely to occur.
Keywords AnimalsAnimals, Genetically ModifiedAntigens/immunologyBlood Coagulation/physiologyComplement Activation/immunologyGraft RejectionGraft SurvivalHumansImmune Tolerance/physiologyImmunosuppressionT-Lymphocytes/immunology*Transplantation, Heterologous/pathology
PMID: 19796067
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Research group Laboratoire d'immunologie translationnelle (856)
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PIERSON, Richard N 3rd et al. Current status of xenotransplantation and prospects for clinical application. In: Xenotransplantation, 2009, vol. 16, n° 5, p. 263-280. doi: 10.1111/j.1399-3089.2009.00534.x https://archive-ouverte.unige.ch/unige:20036

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Deposited on : 2012-04-23

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