UNIGE document Scientific Article - Case report
previous document  unige:19881  next document
add to browser collection
Title

Glomerulosclerose segmentaire et focale avec collapsus du flocculus induite par les bisphosphonates; presentation de deux cas cliniques et revue de la litterature

Authors
Jotterand, Valérie
Published in Néphrologie & thérapeutique. 2009, vol. 5, no. 2, p. 134-138
Abstract Collapsing focal segmental glomerulosclerosis is well described in its idiopathic form, mostly seen in young African American patients, and in association with HIV virus. Its clinical presentation typically includes proteinuria and renal failure rapidly progressing to end stage renal disease. However, a new form has recently been described related to treatment with high doses of intravenous bisphosphonates, especially pamidronate. We report two cases of collapsing focal segmental glomerulosclerosis in patients treated with intravenous pamidronate. In opposition to previous reports, interruption of pamidronate administration did not improve renal function. The latter should be evaluated before initiating treatment with bisphosphonates and regularly monitored. For patients with chronic kidney disease, introduction of bisphosphonates should be reconsidered given the risk of rapid progression to end stage renal disease and the lack of evidence for reduction of fracture risk in this population.
Keywords AgedAntineoplastic Combined Chemotherapy Protocols/therapeutic useDiphosphonates/administration & dosage/*adverse effects/pharmacologyFemaleFractures, Spontaneous/drug therapy/etiology/prevention & controlGlomerulosclerosis, Focal Segmental/*chemically inducedHumansInfusions, IntravenousKidney Diseases/etiology/physiopathologyKidney Failure, Chronic/etiology/therapyKidney Glomerulus/drug effects/pathologyMaleMultiple Myeloma/complications/drug therapyPodocytes/drug effects/pathologyRenal Dialysis
Identifiers
PMID: 19013118
Full text
Structures
Research groups Groupe Pierre-Yves Martin (néphrologie) (30)
Analyse protéomique et Analyse génomique des maladies rénales (659)
Citation
(ISO format)
JOTTERAND, Valérie et al. Glomerulosclerose segmentaire et focale avec collapsus du flocculus induite par les bisphosphonates; presentation de deux cas cliniques et revue de la litterature. In: Néphrologie & thérapeutique, 2009, vol. 5, n° 2, p. 134-138. https://archive-ouverte.unige.ch/unige:19881

194 hits

0 download

Update

Deposited on : 2012-04-23

Export document
Format :
Citation style :