Article - Limited access to UNIGE
Other version: http://pdn.sciencedirect.com/science?_ob=MiamiImageURL&_cid=272185&_user=9565874&_pii=S1471490609001719&_check=y&_ori...
Lymph node tumor metastases: more susceptible than primary tumors to CD8(+) T-cell immune destruction
|Published in||Trends in Immunology. 2009, vol. 30, no. 12, p. 569-573|
|Abstract||Hematopoietic cells, and more particularly, dendritic cells are so called "professional" antigen-presenting cells, which prime CD8(+) T-cell responses. They achieve this by taking up antigens and presenting them to CD8(+) T cells in the draining lymph nodes. This process is called cross-presentation (XP). For most developing tumors, XP of tumor antigens results in CD8(+) T-cell tolerance. In addition to XP, direct presentation by any kind of cell can also occur in lymph nodes. We discuss here how a non-hematopoietic cell can efficiently prime CD8(+) T cells by direct presentation in lymph nodes. Such a T-cell activation pathway is likely to be of importance for the control of cancer metastases that use the lymphatic system to spread.|
|Keywords||Animals — Antigen Presentation — Antigens, Neoplasm/metabolism — CD8-Positive T-Lymphocytes/*immunology/metabolism/pathology — Cross-Priming — Cytotoxicity, Immunologic — Dendritic Cells/*immunology/metabolism — Humans — *Immunotherapy, Adoptive — Lymph Nodes/*immunology/*metabolism/pathology — Lymphatic Metastasis/*immunology/prevention & control|
|CONTASSOT, Emmanuel et al. Lymph node tumor metastases: more susceptible than primary tumors to CD8(+) T-cell immune destruction. In: Trends in Immunology, 2009, vol. 30, n° 12, p. 569-573. https://archive-ouverte.unige.ch/unige:19750|