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Lymph node tumor metastases: more susceptible than primary tumors to CD8(+) T-cell immune destruction

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Published in Trends in Immunology. 2009, vol. 30, no. 12, p. 569-573
Abstract Hematopoietic cells, and more particularly, dendritic cells are so called "professional" antigen-presenting cells, which prime CD8(+) T-cell responses. They achieve this by taking up antigens and presenting them to CD8(+) T cells in the draining lymph nodes. This process is called cross-presentation (XP). For most developing tumors, XP of tumor antigens results in CD8(+) T-cell tolerance. In addition to XP, direct presentation by any kind of cell can also occur in lymph nodes. We discuss here how a non-hematopoietic cell can efficiently prime CD8(+) T cells by direct presentation in lymph nodes. Such a T-cell activation pathway is likely to be of importance for the control of cancer metastases that use the lymphatic system to spread.
Keywords AnimalsAntigen PresentationAntigens, Neoplasm/metabolismCD8-Positive T-Lymphocytes/*immunology/metabolism/pathologyCross-PrimingCytotoxicity, ImmunologicDendritic Cells/*immunology/metabolismHumans*Immunotherapy, AdoptiveLymph Nodes/*immunology/*metabolism/pathologyLymphatic Metastasis/*immunology/prevention & control
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PMID: 19837632
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CONTASSOT, Emmanuel et al. Lymph node tumor metastases: more susceptible than primary tumors to CD8(+) T-cell immune destruction. In: Trends in Immunology, 2009, vol. 30, n° 12, p. 569-573. https://archive-ouverte.unige.ch/unige:19750

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Deposited on : 2012-04-23

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