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Scientific article
English

Lymph node tumor metastases: more susceptible than primary tumors to CD8(+) T-cell immune destruction

Published inTrends in immunology, vol. 30, no. 12, p. 569-573
Publication date2009
Abstract

Hematopoietic cells, and more particularly, dendritic cells are so called "professional" antigen-presenting cells, which prime CD8(+) T-cell responses. They achieve this by taking up antigens and presenting them to CD8(+) T cells in the draining lymph nodes. This process is called cross-presentation (XP). For most developing tumors, XP of tumor antigens results in CD8(+) T-cell tolerance. In addition to XP, direct presentation by any kind of cell can also occur in lymph nodes. We discuss here how a non-hematopoietic cell can efficiently prime CD8(+) T cells by direct presentation in lymph nodes. Such a T-cell activation pathway is likely to be of importance for the control of cancer metastases that use the lymphatic system to spread.

Keywords
  • Animals
  • Antigen Presentation
  • Antigens, Neoplasm/metabolism
  • CD8-Positive T-Lymphocytes/*immunology/metabolism/pathology
  • Cross-Priming
  • Cytotoxicity, Immunologic
  • Dendritic Cells/*immunology/metabolism
  • Humans
  • *Immunotherapy, Adoptive
  • Lymph Nodes/*immunology/*metabolism/pathology
  • Lymphatic Metastasis/*immunology/prevention & control
Citation (ISO format)
CONTASSOT, Emmanuel et al. Lymph node tumor metastases: more susceptible than primary tumors to CD8(+) T-cell immune destruction. In: Trends in immunology, 2009, vol. 30, n° 12, p. 569–573. doi: 10.1016/j.it.2009.08.001
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ISSN of the journal1471-4906
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