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Title

Macrofollicular variant of follicular thyroid carcinoma: a clinical, cytologic, morphologic, and image analysis study of a unique case

Authors
Gremaud, Magali
Moulin, Cecile Stephan
Scheidegger, Christof
Published in Annals of Diagnostic Pathology. 2009, vol. 13, no. 2, p. 101-105
Abstract Thyroid lesions composed of large follicles that contain abundant colloid are usually regarded as benign hyperplastic or adenomatous nodules both by fine-needle aspiration cytology and histology. In such cases, the pathologist is less likely to request a complete inclusion of the capsule into paraffin block and to look for vascular and/or capsular invasion, the only criteria that permit the differential diagnosis between a benign nodule and a follicular carcinoma. We report the first case of a follicular thyroid carcinoma composed predominantly (>90%) of macrofollicles with a surface area that was up to 5 times larger than the surface area of normal follicles, as calculated with an image analysis system. Capsular invasion was detected in 2 separate foci. The tumor was classified as a minimally invasive follicular carcinoma, macrofollicular variant. This case is detailed to highlight the potential pitfall that may arise from an incomplete histological analysis of a macrofollicular lesion, with particular attention paid to the differential diagnoses.
Keywords Adenocarcinoma, Follicular/*pathologyAdenoma/pathologyAdultDiagnosis, DifferentialFemaleHumansHyperplasia/pathologyImage Interpretation, Computer-AssistedImmunohistochemistryThyroid Neoplasms/*pathology
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PMID: 19302958
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BONGIOVANNI, Massimo et al. Macrofollicular variant of follicular thyroid carcinoma: a clinical, cytologic, morphologic, and image analysis study of a unique case. In: Annals of Diagnostic Pathology, 2009, vol. 13, n° 2, p. 101-105. https://archive-ouverte.unige.ch/unige:19691

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Deposited on : 2012-04-23

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