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Malignant irreversible intestinal obstruction: the powerful association of octreotide to corticosteroids, antiemetics, and analgesics

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Published in American Journal of Hospice and Palliative Medicine. 2009, vol. 26, no. 2, p. 84-88
Abstract In the case of malignant intestinal obstruction, surgery often carries important mortality and morbidity risks, and feasibility is neither realistic nor reasonable. A total of 4 clinical cases of intestinal obstruction caused by advanced gastrointestinal cancers in their terminal phase are described. The association of analgesics, corticosteroids, antiemetics, and octreotide was effective to relieve symptoms of intestinal obstruction for the remaining lifetime. The insertion of a nasogastric tube was avoided in 3 of 4 cases. Death occurred 51, 56, and 64 days after clinical and radiological diagnosis of irreversible intestinal obstruction. This combination of drugs appears very powerful and well tolerated. The relatively long survival that was observed should encourage future studies of longer half-life somatostatin analogues with no need of continuous infusion or multiple daily injections.
Keywords Adrenal Cortex Hormones/*therapeutic useAdultAgedAnalgesics/*therapeutic useFatal OutcomeFemaleGastrointestinal Agents/*therapeutic useGastrointestinal Neoplasms/complicationsHumansIntestinal Obstruction/*drug therapy/etiologyMaleMiddle AgedOctreotide/*therapeutic usePrognosisTerminal Care/*methodsTerminally Ill
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PMID: 19088264
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Research group Qualité de vie des personnes âgées et vieillissantes (709)
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(ISO format)
WEBER, Catherine, ZULIAN, Gilbert. Malignant irreversible intestinal obstruction: the powerful association of octreotide to corticosteroids, antiemetics, and analgesics. In: American Journal of Hospice and Palliative Medicine, 2009, vol. 26, n° 2, p. 84-88. https://archive-ouverte.unige.ch/unige:19587

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Deposited on : 2012-04-23

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