Zinc increases the effects of essential amino acids-whey protein supplements in frail elderly
|Published in||Journal of Nutrition, Health and Aging. 2009, vol. 13, no. 6, p. 491-497|
|Abstract||Protein undernutrition is frequent in the elderly. It contributes to the development of osteoporosis, possibly via lower IGF-I. Dietary zinc can influence IGF-I production. OBJECTIVES: To determine the influence of dietary zinc addition on IGF-I and bone turnover responses to essential amino acids-whey (EAA-W) protein supplements in frail elderly. DESIGN AND SETTING: A daily oral protein supplement was given to hospitalized patients for 4 weeks. On a randomized, double-blind basis, patients received either an additional 30 mg/day of zinc or control. PARTICIPANTS: Sixty-one hospitalized elderly aged 66.7 to 105.8, with a mini-nutritional assessment score between 17 and 24 were enrolled. MEASUREMENTS: Activities of daily living; dietary intakes; serum IGF-I, IGF-BP3, CrossLapsTM, osteocalcin and zinc were measured before and after 1, 2 and 4 weeks of protein supplementation. RESULTS: Serum IGF-I rapidly increased in both groups. Zinc accelerated this increase with changes of +48.2 +/- 14.3 and +22.4 +/- 4.7% (p < .05) by 1 week, in the zinc-supplemented and control groups, respectively. Zinc significantly decreased the serum bone resorption marker CrossLapsTM by already 1 week. Activities of daily living improved by +27.0 +/- 3.1 and +18.3 +/- 4.5% in zinc-supplemented and control groups, respectively. CONCLUSION: In the elderly, zinc supplementation accelerated the serum IGF-I response to EAA-W protein by 1 week and decreased a biochemical marker of bone resorption.|
|Keywords||*Activities of Daily Living — Aged, 80 and over — Amino Acids, Essential/pharmacology/*therapeutic use — Bone Resorption/diet therapy/*drug therapy — Collagen/*blood — Combined Modality Therapy — Dietary Proteins/pharmacology/therapeutic use — Dietary Supplements — Double-Blind Method — Female — Frail Elderly — Humans — Insulin-Like Growth Factor I/*metabolism — Male — Milk Proteins/pharmacology/therapeutic use — Peptide Fragments/*blood — Protein-Energy Malnutrition/diet therapy/*drug therapy — Zinc/pharmacology/*therapeutic use|
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|Research groups||Etudes précliniques de l'ostéoporose (606)|
Nutrition et os (66)
|RODONDI, A. et al. Zinc increases the effects of essential amino acids-whey protein supplements in frail elderly. In: Journal of Nutrition, Health and Aging, 2009, vol. 13, n° 6, p. 491-497. doi: 10.1007/s12603-009-0117-7 https://archive-ouverte.unige.ch/unige:19575|