Scientific article
Open access

Zinc increases the effects of essential amino acids-whey protein supplements in frail elderly

Published inThe Journal of nutrition, health & aging, vol. 13, no. 6, p. 491-497
Publication date2009

Protein undernutrition is frequent in the elderly. It contributes to the development of osteoporosis, possibly via lower IGF-I. Dietary zinc can influence IGF-I production. OBJECTIVES: To determine the influence of dietary zinc addition on IGF-I and bone turnover responses to essential amino acids-whey (EAA-W) protein supplements in frail elderly. DESIGN AND SETTING: A daily oral protein supplement was given to hospitalized patients for 4 weeks. On a randomized, double-blind basis, patients received either an additional 30 mg/day of zinc or control. PARTICIPANTS: Sixty-one hospitalized elderly aged 66.7 to 105.8, with a mini-nutritional assessment score between 17 and 24 were enrolled. MEASUREMENTS: Activities of daily living; dietary intakes; serum IGF-I, IGF-BP3, CrossLapsTM, osteocalcin and zinc were measured before and after 1, 2 and 4 weeks of protein supplementation. RESULTS: Serum IGF-I rapidly increased in both groups. Zinc accelerated this increase with changes of +48.2 +/- 14.3 and +22.4 +/- 4.7% (p < .05) by 1 week, in the zinc-supplemented and control groups, respectively. Zinc significantly decreased the serum bone resorption marker CrossLapsTM by already 1 week. Activities of daily living improved by +27.0 +/- 3.1 and +18.3 +/- 4.5% in zinc-supplemented and control groups, respectively. CONCLUSION: In the elderly, zinc supplementation accelerated the serum IGF-I response to EAA-W protein by 1 week and decreased a biochemical marker of bone resorption.

  • Activities of Daily Living
  • Aged, 80 and over
  • Amino Acids, Essential/pharmacology/therapeutic use
  • Bone Resorption/diet therapy/drug therapy
  • Collagen/blood
  • Combined Modality Therapy
  • Dietary Proteins/pharmacology/therapeutic use
  • Dietary Supplements
  • Double-Blind Method
  • Female
  • Frail Elderly
  • Humans
  • Insulin-Like Growth Factor I/metabolism
  • Male
  • Milk Proteins/pharmacology/therapeutic use
  • Peptide Fragments/blood
  • Protein-Energy Malnutrition/diet therapy/drug therapy
  • Zinc/pharmacology/therapeutic use
NoteOpen Access - Licence nationale Springer
Citation (ISO format)
RODONDI, A. et al. Zinc increases the effects of essential amino acids-whey protein supplements in frail elderly. In: The Journal of nutrition, health & aging, 2009, vol. 13, n° 6, p. 491–497. doi: 10.1007/s12603-009-0099-5
Main files (1)
Article (Published version)
ISSN of the journal1279-7707

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