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Title

Zinc increases the effects of essential amino acids-whey protein supplements in frail elderly
Authors
Rodondi, A.
Ammann, Patrick
Ghilardi-Beuret, S.
Rizzoli, René
Published in Journal of Nutrition, Health and Aging. 2009, vol. 13, no. 6, p. 491-497
Abstract Protein undernutrition is frequent in the elderly. It contributes to the development of osteoporosis, possibly via lower IGF-I. Dietary zinc can influence IGF-I production. OBJECTIVES: To determine the influence of dietary zinc addition on IGF-I and bone turnover responses to essential amino acids-whey (EAA-W) protein supplements in frail elderly. DESIGN AND SETTING: A daily oral protein supplement was given to hospitalized patients for 4 weeks. On a randomized, double-blind basis, patients received either an additional 30 mg/day of zinc or control. PARTICIPANTS: Sixty-one hospitalized elderly aged 66.7 to 105.8, with a mini-nutritional assessment score between 17 and 24 were enrolled. MEASUREMENTS: Activities of daily living; dietary intakes; serum IGF-I, IGF-BP3, CrossLapsTM, osteocalcin and zinc were measured before and after 1, 2 and 4 weeks of protein supplementation. RESULTS: Serum IGF-I rapidly increased in both groups. Zinc accelerated this increase with changes of +48.2 +/- 14.3 and +22.4 +/- 4.7% (p < .05) by 1 week, in the zinc-supplemented and control groups, respectively. Zinc significantly decreased the serum bone resorption marker CrossLapsTM by already 1 week. Activities of daily living improved by +27.0 +/- 3.1 and +18.3 +/- 4.5% in zinc-supplemented and control groups, respectively. CONCLUSION: In the elderly, zinc supplementation accelerated the serum IGF-I response to EAA-W protein by 1 week and decreased a biochemical marker of bone resorption.
Keywords *Activities of Daily Living — Aged, 80 and over — Amino Acids, Essential/pharmacology/*therapeutic use — Bone Resorption/diet therapy/*drug therapy — Collagen/*blood — Combined Modality Therapy — Dietary Proteins/pharmacology/therapeutic use — Dietary Supplements — Double-Blind Method — Female — Frail Elderly — Humans — Insulin-Like Growth Factor I/*metabolism — Male — Milk Proteins/pharmacology/therapeutic use — Peptide Fragments/*blood — Protein-Energy Malnutrition/diet therapy/*drug therapy — Zinc/pharmacology/*therapeutic use
Identifiers
PMID: 19536417
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Structures
Faculté de médecine / Section de médecine clinique / Département de médecine interne des spécialités
Faculté de médecine / Section de médecine clinique / Département de médecine interne générale, de réhabilitation et de gériatrie
Research groups Etudes précliniques de l'ostéoporose (606)
Nutrition et os (66)
Citation
(ISO format) 		RODONDI, A. et al. Zinc increases the effects of essential amino acids-whey protein supplements in frail elderly. In: Journal of Nutrition, Health and Aging, 2009, vol. 13, n° 6, p. 491-497. https://archive-ouverte.unige.ch/unige:19575

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Deposited on : 2012-04-23

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