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Title

Reconstitution of the immune system after hematopoietic stem cell transplantation in humans

Authors
Storek, Jan
Geddes, Michelle
Khan, Faisal
Published in Seminars in Immunopathology. 2008, vol. 30, no. 4, p. 425-437
Collection Open Access - Licence nationale Springer
Abstract Hematopoietic stem cell transplantation is associated with a severe immune deficiency. As a result, the patient is at high risk of infections. Innate immunity, including epithelial barriers, monocytes, granulocytes, and NK cells recovers within weeks after transplantation. By contrast, adaptive immunity recovers much slower. B- and T-cell counts normalize during the first months after transplantation, but in particular, T-cell immunity may remain impaired for years. During the last decade, much of the underlying mechanisms have been identified. These insights may provide new therapies to accelerate recovery.
Keywords Antigen-Presenting Cells/cytology/immunologyB-Lymphocytes/cytology/immunology*Hematopoietic Stem Cell TransplantationHumansImmune System/*cytology/*immunologyKiller Cells, Natural/cytology/immunologyT-Lymphocytes/cytology/immunology
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PMID: 18949477
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STOREK, Jan et al. Reconstitution of the immune system after hematopoietic stem cell transplantation in humans. In: Seminars in Immunopathology, 2008, vol. 30, n° 4, p. 425-437. doi: 10.1007/s00281-008-0132-5 https://archive-ouverte.unige.ch/unige:19215

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Deposited on : 2012-03-27

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