

Other version: http://www.springerlink.com/content/k4lm3404t5434064/fulltext.pdf
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Reconstitution of the immune system after hematopoietic stem cell transplantation in humans |
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Published in | Seminars in immunopathology. 2008, vol. 30, no. 4, p. 425-437 | |
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Open Access - Licence nationale Springer |
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Abstract | Hematopoietic stem cell transplantation is associated with a severe immune deficiency. As a result, the patient is at high risk of infections. Innate immunity, including epithelial barriers, monocytes, granulocytes, and NK cells recovers within weeks after transplantation. By contrast, adaptive immunity recovers much slower. B- and T-cell counts normalize during the first months after transplantation, but in particular, T-cell immunity may remain impaired for years. During the last decade, much of the underlying mechanisms have been identified. These insights may provide new therapies to accelerate recovery. | |
Keywords | Antigen-Presenting Cells/cytology/immunology — B-Lymphocytes/cytology/immunology — *Hematopoietic Stem Cell Transplantation — Humans — Immune System/*cytology/*immunology — Killer Cells, Natural/cytology/immunology — T-Lymphocytes/cytology/immunology | |
Identifiers | PMID: 18949477 | |
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![]() ![]() Other version: http://www.springerlink.com/content/k4lm3404t5434064/fulltext.pdf |
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Citation (ISO format) | STOREK, Jan et al. Reconstitution of the immune system after hematopoietic stem cell transplantation in humans. In: Seminars in immunopathology, 2008, vol. 30, n° 4, p. 425-437. doi: 10.1007/s00281-008-0132-5 https://archive-ouverte.unige.ch/unige:19215 |