Reconstitution of the immune system after hematopoietic stem cell transplantation in humans

Storek, Jan; Geddes, Michelle; Khan, Faisal; Huard, Bertrand; Helg, Claudine; Chalandon, Yves; Passweg, Jakob; Roosnek, Eddy Emile

doi:10.1007/s00281-008-0132-5

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Title		Reconstitution of the immune system after hematopoietic stem cell transplantation in humans
Authors		Storek, Jan Geddes, Michelle Khan, Faisal Huard, Bertrand Helg, Claudine Chalandon, Yves Passweg, Jakob Roosnek, Eddy Emile
Published in		Seminars in immunopathology. 2008, vol. 30, no. 4, p. 425-437
Collection		Open Access - Licence nationale Springer
Abstract		Hematopoietic stem cell transplantation is associated with a severe immune deficiency. As a result, the patient is at high risk of infections. Innate immunity, including epithelial barriers, monocytes, granulocytes, and NK cells recovers within weeks after transplantation. By contrast, adaptive immunity recovers much slower. B- and T-cell counts normalize during the first months after transplantation, but in particular, T-cell immunity may remain impaired for years. During the last decade, much of the underlying mechanisms have been identified. These insights may provide new therapies to accelerate recovery.
Keywords		Antigen-Presenting Cells/cytology/immunology — B-Lymphocytes/cytology/immunology — Hematopoietic Stem Cell Transplantation — Humans — Immune System/cytology/*immunology — Killer Cells, Natural/cytology/immunology — T-Lymphocytes/cytology/immunology
Identifiers		DOI: 10.1007/s00281-008-0132-5 PMID: 18949477
Full text		Article (Published version) - Free access Other version: http://www.springerlink.com/content/k4lm3404t5434064/fulltext.pdf
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine
Citation (ISO format)		STOREK, Jan et al. Reconstitution of the immune system after hematopoietic stem cell transplantation in humans. In: Seminars in immunopathology, 2008, vol. 30, n° 4, p. 425-437. doi: 10.1007/s00281-008-0132-5 https://archive-ouverte.unige.ch/unige:19215