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Postsynaptic density protein PSD-95 expression in Alzheimer's disease and okadaic acid induced neuritic retraction

Leuba, Genevieve
Vernay, Andre
Carnal, Beatrice
Kraftsik, Rudolf
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Published in Neurobiology of disease. 2008, vol. 30, no. 3, p. 408-419
Abstract In order to understand how plasticity is related to neurodegeneration, we studied synaptic proteins with quantitative immunohistochemistry in the entorhinal cortex from Alzheimer patients and age-matched controls. We observed a significant decrease in presynaptic synaptophysin and an increase in postsynaptic density protein PSD-95, positively correlated with beta amyloid and phosphorylated Tau proteins in Alzheimer cases. Furthermore, Alzheimer-like neuritic retraction was generated in okadaic acid (OA) treated SH-SY5Y neuroblastoma cells with no decrease in PSD-95 expression. However, in a SH-SY5Y clone with decreased expression of transcription regulator LMO4 (as observed in Alzheimer's disease) and increased neuritic length, PSD-95 expression was enhanced but did not change with OA treatment. Therefore, increased PSD-95 immunoreactivity in the entorhinal cortex might result from compensatory mechanisms, as in the SH-SY5Y clone, whereas increased Alzheimer-like Tau phosphorylation is not related to PSD-95 expression, as suggested by the OA-treated cell models.
Keywords AdultAgedAged, 80 and overAlzheimer Disease/genetics/*metabolism/pathologyAmyloid beta-Peptides/metabolismCell Line, TumorCell Survival/drug effects/physiologyFemaleGene Expression Regulation/drug effects/*physiologyHumansIntracellular Signaling Peptides and Proteins/geneticsMaleMembrane Proteins/*biosynthesis/geneticsMiddle AgedNeurites/drug effects/pathology/*physiologyOkadaic Acid/*toxicityPhosphorylationUp-Regulation/geneticsTau Proteins/metabolism
PMID: 18424056
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Research group Groupe Bouras Constantin (neuropsychiatrie) (1)
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LEUBA, Genevieve et al. Postsynaptic density protein PSD-95 expression in Alzheimer's disease and okadaic acid induced neuritic retraction. In: Neurobiology of disease, 2008, vol. 30, n° 3, p. 408-419. doi: 10.1016/j.nbd.2008.02.012 https://archive-ouverte.unige.ch/unige:19185

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Deposited on : 2012-03-27

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