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Title

Stereologic estimates of total spinophilin-immunoreactive spine number in area 9 and the CA1 field: relationship with the progression of Alzheimer's disease

Authors
Akram, Afia
Christoffel, Daniel
Rocher, Anne B.
Perl, Daniel P.
Morrison, John H.
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Published in Neurobiology of Aging. 2008, vol. 29, no. 9, p. 1296-1307
Abstract The loss of presynaptic markers is thought to represent a strong pathologic correlate of cognitive decline in Alzheimer's disease (AD). Spinophilin is a postsynaptic marker mainly located to the heads of dendritic spines. We assessed total numbers of spinophilin-immunoreactive puncta in the CA1 and CA3 fields of hippocampus and area 9 in 18 elderly individuals with various degrees of cognitive decline. The decrease in spinophilin-immunoreactivity was significantly related to both Braak neurofibrillary tangle (NFT) staging and clinical severity but not A beta deposition staging. The total number of spinophilin-immunoreactive puncta in CA1 field and area 9 were significantly related to MMSE scores and predicted 23.5 and 61.9% of its variability. The relationship between total number of spinophilin-immunoreactive puncta in CA1 field and MMSE scores did not persist when adjusting for Braak NFT staging. In contrast, the total number of spinophilin-immunoreactive puncta in area 9 was still significantly related to the cognitive outcome explaining an extra 9.6% of MMSE and 25.6% of the Clinical Dementia Rating scores variability. Our data suggest that neocortical dendritic spine loss is an independent parameter to consider in AD clinicopathologic correlations.
Keywords AgedAlzheimer Disease/*metabolism/*pathologyBiological Markers/metabolismDendritic Spines/*metabolism/*pathologyDisease ProgressionFemaleHippocampus/*metabolism/*pathologyHumansImmunohistochemistryMaleMicrofilament Proteins/*metabolismNerve Net/metabolism/pathologyNerve Tissue Proteins/*metabolismTissue Distribution
Identifiers
PMID: 17420070
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Research groups Groupe Bouras Constantin (neuropsychiatrie) (1)
Groupe Giannakopoulos Panteleimon (psychiatrie générale) (201)
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AKRAM, Afia et al. Stereologic estimates of total spinophilin-immunoreactive spine number in area 9 and the CA1 field: relationship with the progression of Alzheimer's disease. In: Neurobiology of Aging, 2008, vol. 29, n° 9, p. 1296-1307. https://archive-ouverte.unige.ch/unige:19184

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Deposited on : 2012-03-27

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