INTRODUCTION: The optical coherence tomography (OCT) Visante provides easy, high-resolution observation free of contact with the cornea and anterior segment. We present the progression of a neurotrophic corneal ulcer treated with amniotic membrane grafts studied with this system. METHODS: A 71-year-old patient with facial nerve paresis secondary to vestibular schwannoma surgery presented with a neurotrophic perforated corneal ulcer. Since medical treatment had failed, we performed an amniotic membrane graft. The OCT Visante was used for follow-up for 2 months. RESULTS: Progression was slow but the perforation eventually closed. Cicatrization of the corneal ulcer was followed with the OCT Visante to document the healing process and corneal thickness. CONCLUSION: Optical coherence tomography Visante provides easy visualization and high-resolution documentation with no contact with the healing corneal ulcerations.