

Other version: http://www.nature.com/cdd/journal/v15/n11/full/cdd2008119a.html
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The antiviral adaptor proteins Cardif and Trif are processed and inactivated by caspases |
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Authors | ||
Published in | Cell death and differentiation. 2008, vol. 15, no. 11, p. 1804-11 | |
Abstract | The outcome of a viral infection depends on the interplay between the host's capacity to trigger potent antiviral responses and viral mechanisms that counteract them. Although Toll-like receptor (TLR)-3, which recognizes virally derived double-stranded (ds) RNA, transmits downstream antiviral signaling through the TIR adaptor Trif (TICAM-1), viral RNA-sensing RIG-like helicases (RLHs) use the mitochondrial-bound CARD protein Cardif (IPS-1/MAVS/VISA). The importance of these two antiviral signaling pathways is reflected by the fact that both adaptors are inhibited through specific cleavage triggered by the hepatitis C virus serine protease NS3-4A. Here, we show that inactivation can also occur through cellular caspases activated by various pro-apoptotic signals. Upon caspase-dependent cleavage both adaptors loose their capacity to activate the transcription factors interferon regulatory factors (IRF) and NF-kappaB. Importantly, poliovirus infection triggers a caspase-dependent cleavage of Cardif, suggesting that some viruses may activate caspases not only as a mean to facilitate shedding and replication, but also to impair antiviral responses. | |
Keywords | Adaptor Proteins, Signal Transducing/metabolism — Adaptor Proteins, Vesicular Transport/metabolism — Antiviral Agents/metabolism — Caspases/metabolism — Hela Cells — Humans — Interferon Regulatory Factors/metabolism — Models, Biological — Poliovirus/physiology — Protein Processing, Post-Translational | |
Identifiers | DOI: 10.1038/cdd.2008.119 PMID: 18756281 | |
Full text |
![]() ![]() Other version: http://www.nature.com/cdd/journal/v15/n11/full/cdd2008119a.html |
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Structures | ||
Research group | Régulation traductionnelle dans les cellules de mammifère (631) | |
Citation (ISO format) | REBSAMEN, Manuele et al. The antiviral adaptor proteins Cardif and Trif are processed and inactivated by caspases. In: Cell death and differentiation, 2008, vol. 15, n° 11, p. 1804-11. doi: 10.1038/cdd.2008.119 https://archive-ouverte.unige.ch/unige:1889 |