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SLP-2 is required for stress-induced mitochondrial hyperfusion

Karbowski, Mariusz
Clerc, Pascaline
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Published in EMBO journal. 2009, vol. 28, no. 11, p. 1589-600
Abstract Mitochondria are dynamic organelles, the morphology of which results from an equilibrium between two opposing processes, fusion and fission. Mitochondrial fusion relies on dynamin-related GTPases, the mitofusins (MFN1 and 2) in the outer mitochondrial membrane and OPA1 (optic atrophy 1) in the inner mitochondrial membrane. Apart from a role in the maintenance of mitochondrial DNA, little is known about the physiological role of mitochondrial fusion. Here we report that mitochondria hyperfuse and form a highly interconnected network in cells exposed to selective stresses. This process precedes mitochondrial fission when it is triggered by apoptotic stimuli such as UV irradiation or actinomycin D. Stress-induced mitochondrial hyperfusion (SIMH) is independent of MFN2, BAX/BAK, and prohibitins, but requires L-OPA1, MFN1, and the mitochondrial inner membrane protein SLP-2. In the absence of SLP-2, L-OPA1 is lost and SIMH is prevented. SIMH is accompanied by increased mitochondrial ATP production and represents a novel adaptive pro-survival response against stress.
Keywords Adenosine Triphosphate/metabolismAnimalsCells, CulturedDactinomycin/toxicityFibroblasts/drug effects/physiology/radiation effectsGTP Phosphohydrolases/physiologyMembrane Proteins/physiologyMiceMitochondria/drug effects/metabolism/physiology/radiation effectsStress, PhysiologicalUltraviolet Rays
PMID: 19360003
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Research group Translocation des protéines à travers les membranes (169)
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TONDERA, Daniel et al. SLP-2 is required for stress-induced mitochondrial hyperfusion. In: EMBO journal, 2009, vol. 28, n° 11, p. 1589-600. doi: 10.1038/emboj.2009.89 https://archive-ouverte.unige.ch/unige:18589

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Deposited on : 2012-03-02

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