Scientific article
Open access

Poles apart: prokaryotic polar organelles and their spatial regulation

Published inCold Spring Harbor perspectives in biology, vol. 3, no. 3
Publication date2011

While polar organelles hold the key to understanding the fundamentals of cell polarity and cell biological principles in general, they have served in the past merely for taxonomical purposes. Here, we highlight recent efforts in unraveling the molecular basis of polar organelle positioning in bacterial cells. Specifically, we detail the role of members of the Ras-like GTPase superfamily and coiled-coil-rich scaffolding proteins in modulating bacterial cell polarity and in recruiting effector proteins to polar sites. Such roles are well established for eukaryotic cells, but not for bacterial cells that are generally considered diffusion-limited. Studies on spatial regulation of protein positioning in bacterial cells, though still in their infancy, will undoubtedly experience a surge of interest, as comprehensive localization screens have yielded an extensive list of (polarly) localized proteins, potentially reflecting subcellular sites of functional specialization predicted for organelles.

  • Bacterial Proteins/physiology
  • Cell Movement/physiology
  • Cell Polarity/physiology
  • Fimbriae, Bacterial/physiology
  • Molecular Motor Proteins/metabolism
  • Organelles/physiology/ultrastructure
  • Polysaccharides/metabolism
  • Prokaryotic Cells/cytology
  • Ras Proteins/metabolism
Citation (ISO format)
KIRKPATRICK, Clare, VIOLLIER, Patrick. Poles apart: prokaryotic polar organelles and their spatial regulation. In: Cold Spring Harbor perspectives in biology, 2011, vol. 3, n° 3. doi: 10.1101/cshperspect.a006809
Main files (1)
Article (Published version)
ISSN of the journal1943-0264

Technical informations

Creation01/27/2012 8:59:00 PM
First validation01/27/2012 8:59:00 PM
Update time03/14/2023 5:07:40 PM
Status update03/14/2023 5:07:40 PM
Last indexation01/15/2024 10:57:50 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack