UNIGE document Scientific Article
previous document  unige:18224  next document
add to browser collection

Caffeine extends yeast lifespan by targeting TORC1

Published in Molecular microbiology. 2008, vol. 69, no. 1, p. 277-85
Abstract Dietary nutrient limitation (dietary restriction) is known to increase lifespan in a variety of organisms. Although the molecular events that couple dietary restriction to increased lifespan are not clear, studies of the model eukaryote Saccharomyces cerevisiae have implicated several nutrient-sensitive kinases, including the target of rapamycin complex 1 (TORC1), Sch9, protein kinase A (PKA) and Rim15. We have recently demonstrated that TORC1 activates Sch9 by direct phosphorylation. We now show that Sch9 inhibits Rim15 also by direct phosphorylation. Treatment of yeast cells with the specific TORC1 inhibitor rapamycin or caffeine releases Rim15 from TORC1-Sch9-mediated inhibition and consequently increases lifespan. This kinase cascade appears to have been evolutionarily conserved, suggesting that caffeine may extend lifespan in other eukaryotes, including man.
Keywords Caffeine/pharmacologyGene Expression Regulation, Fungal/drug effectsProtein Kinases/genetics/metabolismProtein-Serine-Threonine Kinases/genetics/metabolismSaccharomyces cerevisiae/drug effects/genetics/physiologySaccharomyces cerevisiae Proteins/genetics/metabolismSignal TransductionSirolimus/pharmacology
PMID: 18513215
Full text
Article (Published version) (437 Kb) - public document Free access
(ISO format)
WANKE, Valeria et al. Caffeine extends yeast lifespan by targeting TORC1. In: Molecular microbiology, 2008, vol. 69, n° 1, p. 277-85. https://archive-ouverte.unige.ch/unige:18224

245 hits



Deposited on : 2012-01-30

Export document
Format :
Citation style :