UNIGE document Scientific Article
previous document  unige:18123  next document
add to browser collection

The effect of keratolytic agents on the permeability of three imidazole antimycotic drugs through the human nail

Quintanar-Guerrero, D
Ganem-Quintanar, A
Tapia-Olguín, P
Published in Drug Development and Industrial Pharmacy. 1998, vol. 24, no. 7, p. 685-90
Abstract The permeability of three imidazole antimycotics (miconazole nitrate, ketoconazole, and itraconazole) through the free edge of healthy human nail was evaluated in vitro using side-by-side diffusion cells. The influence of keratolytic substances (papain, urea, and salicylic acid) on the permeability of the antimycotics was also studied. The results suggested that the nail constituted an impermeable barrier for these antimycotics; it could be considered that the nail behaved as a hydrophilic gel membrane, through which drugs of low solubility could not permeate. The use of ethanol did not promote the passage of any of the antimycotic drugs. Although scanning electron microscopy indicated that the keratolytic substances had a significant effect on the nail surface (papain > salicylic acid > urea), the passage of the three antimycotics was not improved by pretreatment with salicylic acid alone (20% for 10 days), or by the application of the drug in a 40% urea solution. It was found that only the combined effects of papain (15% for 1 day) and salicylic acid (20% for 10 days) were capable of enhancing the permeability of the antimycotic.
Keywords Antifungal Agents/pharmacokineticsHumansItraconazole/pharmacokineticsKeratolytic Agents/pharmacologyKetoconazole/pharmacokineticsLinear ModelsMiconazole/pharmacokineticsNails/drug effects/metabolismPapain/pharmacologyPermeabilityReference ValuesSalicylic Acid/pharmacologyUrea/pharmacology
PMID: 9876516
Full text
Article (Published version) (567 Kb) - document accessible for UNIGE members only Limited access to UNIGE
(ISO format)
QUINTANAR-GUERRERO, D et al. The effect of keratolytic agents on the permeability of three imidazole antimycotic drugs through the human nail. In: Drug Development and Industrial Pharmacy, 1998, vol. 24, n° 7, p. 685-90. https://archive-ouverte.unige.ch/unige:18123

225 hits

0 download


Deposited on : 2012-01-20

Export document
Format :
Citation style :