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Scientific article
Open access
English

Accelerated long-term forgetting in patients with acquired brain injury

Published inBrain injury, vol. 38, no. 5, p. 377-389
Publication date2024-04-15
First online date2024-02-22
Abstract

Objective: Recent research suggests that patients with neurological disorders without overt seizures may also experience accelerated long-term forgetting (ALF). This term describes unimpaired learning and memory performance after standard retention intervals, but an excessive rate of forgetting over delays of days or weeks. The objective of this retrospective study was to investigate ALF in patients with an acquired brain injury (ABI) and to associate memory performance with executive functions.

Methods: Verbal memory performance (short-term recall, 30-min recall, 1-week recall) was assessed in 34 adult patients with ABI and compared to a healthy control group (n = 54) using an auditory word learning and memory test.

Results: Repeated measure analysis showed significant effects of time and group as well as interaction effects between time and group regarding recall and recognition performance. Patients with ABI had a significantly impaired 1-week recall and recognition performance compared to the healthy control group. Correlations between recall performance and executive functions were nonsignificant.

Discussion: Our results demonstrate that non-epileptic patients with ABI, especially patients with frontal and fronto-temporal lesions, are prone to ALF. Additionally, our data support the assumption that ALF results from a consolidation impairment since verbal recall and recognition were impaired in patients with ABI.

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Keywords
  • Acquired brain injury
  • Accelerated long-term forgetting
  • Delayed episodic memory recall
  • Executive functions
  • Memory consolidation
  • Adult
  • Humans
  • Memory Disorders / etiology
  • Retrospective Studies
  • Neuropsychological Tests
  • Memory
  • Mental Recall
  • Brain Injuries / complications
Affiliation Not a UNIGE publication
Citation (ISO format)
STUDER, M et al. Accelerated long-term forgetting in patients with acquired brain injury. In: Brain injury, 2024, vol. 38, n° 5, p. 377–389. doi: 10.1080/02699052.2024.2311349
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ISSN of the journal0269-9052
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