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Scientific article
Open access
English

Metabolites in the regulatory risk assessment of pesticides in the EU

Published inFrontiers in toxicology, vol. 5, 1304885
Publication date2023-12-19
First online date2023-12-19
Abstract

A large majority of chemicals is converted into metabolites through xenobiotic-metabolising enzymes. Metabolites may present a spectrum of characteristics varying from similar to vastly different compared with the parent compound in terms of both toxicokinetics and toxicodynamics. In the pesticide arena, the role of metabolism and metabolites is increasingly recognised as a significant factor particularly for the design and interpretation of mammalian toxicological studies and in the toxicity assessment of pesticide/metabolite-associated issues for hazard characterization and risk assessment purposes, including the role of metabolites as parts in various residues in ecotoxicological adversities. This is of particular relevance to pesticide metabolites that are unique to humans in comparison with metabolites found in in vitro or in vivo animal studies, but also to disproportionate metabolites (quantitative differences) between humans and mammalian species. Presence of unique or disproportionate metabolites may underlie potential toxicological concerns. This review aims to present the current state-of-the-art of comparative metabolism and metabolites in pesticide research for hazard and risk assessment, including One Health perspectives, and future research needs based on the experiences gained at the European Food Safety Authority.

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Keywords
  • Analytical methods
  • Disproportionate human metabolite
  • In vitro/in silico testing
  • Pesticide metabolite
  • Risk assessment
  • Unique human metabolite
  • Xenobiotic metabolism
Citation (ISO format)
PELKONEN, Olavi et al. Metabolites in the regulatory risk assessment of pesticides in the EU. In: Frontiers in toxicology, 2023, vol. 5, p. 1304885. doi: 10.3389/ftox.2023.1304885
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ISSN of the journal2673-3080
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